Solubility and dissolution enhancement of ketotifen by solid dispersion technique

Ketotifen [KT] solid dispersions and physical mixtures were prepared with the objective of solubility and dissolution improvement using Hydroxypropyl-Beta-Cyclodextrin [HP-beta-CD], Pluronic 127 [PF-127], Pluronic 68 [PF-68], Polyethylene glycol 6000 [PEG 6000], and Polyethylene glycol 4000 [PEG 4000]. The saturation solubility and in-vitro dissolution studies showed remarkable improvement in solubility and drug dissolution of these new solid dispersions and physical mixtures over pure ketotifen. The XRD, DSC, IR and SEM studies indicated the transformation of crystalline ketotifen [in pure drug] to amorphous ketotifen [in solid dispersions]. This study concluded that the improved solubility as well as drug dissolution of these new ketotifen solid dispersions may be attributed to improved wettability and reduction in drug crystallinity, which can be modulated by appropriate level of hydrophilic carriers

Barriers in controlling glycemic ondition of children suffering from type 1 diabetes

Children with type 1 diabetes have many barriers that prevent them from controlling their blood glucose level. Aim of this study was assess barriers in glycemic control of children suffering from type 1 diabetes. A descriptive design was used for the conduction of the study. The sample of the study consisted of 300 children with type 1 diabetes, their ages ranges from <1 to <18 years, 67.7% of them were males and 32.3% females. A questionnaire sheet was designed by the researcher to collect the demographic characteristics and knowledge about diabetes among study sample in addition to observational check lists to evaluate, the actual practice of the diabetic children regarding insulin preparation and injection, urine and blood testing for glucose and urine testing for ketones. Results and conclusion of the study revealed that barriers of glycemic control include children's characteristics [66.7%], childrens knowledge about diabetes and glycemic control [67.7%], health care facility [53.3%], duration of illness [54.3%] and poor self care practices [68.7%]. There is a relation between the children educational level and barriers of glycemic control and also there is a highly statistical significance difference between barriers of glycemic control and their glycemic condition. The study recommends continuous educational programs which are vital for diabetic children and their care givers to maintain their glycemic control and consequently helping them to identify and manage its barriers