Rosette formation and calcification in retinoblastoma

The presence of rosette formation and of calcification in Retinoblastoma are signs of good prognosis. The more rosettes there are and the more calcium deposits there are the better the chances of long survival and the lesser the possibility of orbital recurrences. This is a confirmation of the conclusions we had in the study of Filipino retinoblastoma in 1954Routine post-operative X-ray irradiation combined with either radon seed implantation or chemotherapy or both is advocated in all cases showing no or minimal rosette formation and calcium depositionPre-operative irradiation is advised in cases where enucleation must be delayed to incite early calcium formationIt is suggested that the presence or absence of rosettes and calcification may be better prognostic signs than the presence or absence of tumor extension or metastasis in early or intraocular stages on retinoblastoma. (Conclusions)

Sulfadiazine in the treatment of senile cataracts

Sulfadizine when given in a small dose (250 mgms. 3 times a day) for a certain period of time (6 months) appears to produce subjective and objective improvements in patients with senile cataract. This work further (on-firms similar observations by the German workers Hackmann and Hackmann. The possible mechanism of the phenomena is predicted to be related to the enzyme contents of the lens, probably the carbonic anhydrase. (Conclusion)