1.
Pakistan Journal of Pharmaceutical Sciences. 2014; 27 (2): 303-307
Dans Anglais
| IMEMR
| ID: emr-138630
Résumé
The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction [7 mg/kg] on monoamines [serotonin and dopamine] modulation [5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes] and its interaction with tyramine [cheese effect]. The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors [50%] with negligible PEA-induced stereotypes [20%]. Additionally, it did not produce a significant increase in the tyramine pressor effects. These results suggest that the dichloromethane fraction of A. catechu nut primarily elevates serotonin levels [probably via monoamine oxidase A inhibition] and does not induce cheese effect