Résumé
OBJECTIVE: To observe the effect of single dose antibiotic is it as efficient as a 24-hour regimen in preventing SSIs in adults undergoing clean, clean contaminated and contaminated elective surgical procedures
STUDY DESIGN: Random, prospective SETTING AND DURATION: Department of general Surgery, Liaquat University Hospital, Jamshoro, Pakistan from May 2011 to April 2012
PATIENTS AND METHODS: A total of 208 patients undergoing general surgical operations were included in the study. The patients were randomly divided into two groups
The single-dose group received 2 grams of ceftriaxone intravenously, whereas the 24-hour group received 2 grams of ceftriaxone intravenously at the time of induction of anaesthesia, followed by 1 g at 8 and 16 hours postoperatively
RESULTS: The administration of ceftriaxone in a single dose regimen was associated with higher rate of SSIs compared with rates for patients receiving the 24-hour regimen [9.6% vs. 6.7%]
CONCLUSION: Multiple doses of prophylactic antibiotics over 24 hours should be used instead of single doses in surgical prophylaxis in clean-contaminated and contaminated procedures