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Article de Chinois | WPRIM | ID: wpr-905667

RÉSUMÉ

Objective:To evaluate the relationship between 1233A/T polymorphism of proteasome subunit α type 6 (PSMA6) gene and cerebral infarction in Chinese Han population. Methods:From January, 2012 to April, 2015, 211 cerebral infarction patients (case group) and 201 healthy controls (control group) were selected in the study. The single nucleotide polymorphism of 1233A/T of PSMA6 gene was identified by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), and genotypes and allele frequency distributions in two groups were analyzed. Results:The frequencies of CC, CT+TT genetype and the C allele all revealed no significant difference between two groups (χ2 < 0.053, P > 0.05). After stratified by gender, the difference among all genetypes and C allele were still not significant between two groups in either male or female (χ2 < 2.735, P > 0.05). Conclusion:The 1233A/T of PSMA6 gene might not be associated with cerebral infarction.

2.
Article de Chinois | WPRIM | ID: wpr-856076

RÉSUMÉ

Objective: To investigate the relationship between G505A polymorphism in the encoding region of thrombin-activated fibrinolysis inhibitor (TAFI) and cerebral infarction in Chinese Han population. Methods: A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect G505A polymorphism in the encoding region of TAFI in 130 patients with cerebral infarction and 118 healthy individuals. Results: The GG genotype of TAFI G505A accounted for 35.4% (46/130) and GA or AA genotype accounted for 64.6% (84/130) in the cerebral infarction group; and they were 49.2% (58/118) and 50.8% (60/118) respectively in the control group. The difference was statistically significant (P = 0.028). The G and A allele frequencies were 60.4% (157/260) and 39.6% (103/260) respectively in the cerebral infarction group, and they were 69.9% (165/236) and 30.1% (71/236) respectively in the control group. The difference was statistically significant (P = 0.026). Multivariate logistic regression analysis showed that G505A polymorphism in the encoding region of TAFI was an independent risk factor for cerebral infarction (OR = 2.660, 95% CI 1.330-5.317, P = 0.006). Conclusion: The TAFI G505A polymorphism may be one of the risk factors for cerebral infarction.

3.
Chinese Journal of Neuromedicine ; (12): 254-257, 2009.
Article de Chinois | WPRIM | ID: wpr-1032710

RÉSUMÉ

Objective To evaluate the association between C291T polymorphism in the coding region of thrombin activatable fibrinolysis inhibitor (TAFI) and cerebral infarction in Chinese Han population. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine C291T polymorphism in the encoding region of TAFI gene in 173 patients with cerebral infarction and 158 healthy control subjects. Results The frequencies of CC genetype and T alleles carriers ofC291T gene were 53.2% (92/173) and 46.8% (81/173) in the case group and 68.4% (108/158) and 31.6% (50/158) in the control group, respectively. Chi-square test showed significant difference in the frequencies of these genotypes between the two groups (P<0.05). The frequencies of C and T alleles were 70.8% (245/346) and 29.2% (101/346) in the case group, and 81.9% (259/316) and18.1% (57/316) in the control group, respectively, also showing significant differences between the two groups (P<0.05). Conclusion C291T polymorphism in the coding region of TAFI gene is significantly associated with cerebral infarction.

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