Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Laboratory Animal Research ; : 209-215, 2012.
Article Dans Anglais | WPRIM | ID: wpr-164971

Résumé

This study used a biomechanical test to evaluate the effects of pentoxifylline administration on the wound healing process of an experimental pressure sore induced in rats. Under general anesthesia and sterile conditions, experimental pressure sores generated by no. 25 Halsted mosquito forceps were inflicted on 12 adult male rats. Pentoxifylline was injected intraperitoneally at a dose of 50 mg/kg daily from the day the pressure sore was generated, for a period of 20 days. At the end of 20 days, rats were sacrificed and skin samples extracted. Samples were biomechanically examined by a material testing instrument for maximum stress (N mm2), work up to maximum force (N), and elastic stiffness (N/mm). In the experimental group, maximum stress (2.05+/-0.15) and work up to maximum force (N/mm) (63.75+/-4.97) were significantly higher than the control group (1.3+/-0.27 and 43.3+/-14.96, P=0.002 and P=0.035, respectively). Pentoxifylline administration significantly accelerated the wound healing process in experimental rats with pressure sores, compared to that of the control group.


Sujets)
Adulte , Animaux , Humains , Mâle , Rats , Anesthésie générale , Culicidae , Pentoxifylline , Escarre , Peau , Instruments chirurgicaux , Cicatrisation de plaie
SÉLECTION CITATIONS
Détails de la recherche