Résumé
Methicillin resistant Staphylococcus aureus [MRSA] is a major nosocomial pathogen causing significant morbidity and mortality. The aim of this study was to evaluate in vitro activity of tigecycline and other new agents against MRSA, isolated from surgical wound and soft tissue infections in an Iranian 1000-bed tertiary hospital. In vitro activity of tigecycline and other antibiotics were tested against 102 strains of Staphylococcus aureus isolated from different patients hospitalized at Milad hospital from May 2008 to June 2008. All strains were identified according to routine bacteriological methods. Susceptibility testing was performed by disk diffusion methods as recommended by Clinical Laboratory Standards Institute [CLSI]. Cefoxitin [30 micri g] disk used for detection of methicillin resistant strains of S.aureus. One hundred two strains of S.aureus were isolated from patients admitted to our hospital. The majority of patients was from surgical wards including open heart, orthopedic ward and had post operation wound infections. Of 102 strains 36[35.3%] isolates were MRSA. All isolates including MRSA strains were susceptible to tigecyline, linozolide and vancmycin. Of 102 isolated strains 96 [94.1%] were susceptible to teicoplanine and six stains [5.9%] were intermediate. Resistant rate to other antibiotics including clindamycinm erythromycin pencillin, co-trimoxazole, rifampicin and ciprofloxacin were 35.3%, 27.7%, 97.7%, 26.5%, 16.7%and 33.7% respectively. All strains of S.aureus, isolated from wound and soft tissue in our hospital were susceptible to tigecyline, linozolide and vancomycin