Relationship between oral poor hygiene and broken teeth with oral tongue squamous cell carcinoma

Previous studies on etiology of squamous cell carcinoma [SCC] of the tongue have reported results with respect to long term exposure to cigarette smoking and alcohol abuse. The aim of this study was to investigate risk factors for SCC of the tongue in a set of patients with minimum exposure to cigarette smoking and alcohol. Sixty four cases with diagnosis of oral tongue SCC were reviewed in this study. The patients underwent surgical management at the educational and therapeutic centers, Imam and Buali Hospitals [Hamedan, Iran] between the dates of January 1990 and December 2006. Eighty five percent of patients were older than 40 years of age. Most of patients had poor oral hygiene, dental decay and halitosis. It appears that poor oral hygiene and nutritional deficiency can be considered as risk factors for the SCC of the tongue in west of Iran

Can aspirin protect or at least attenuate gentamicin ototoxicity in humans?

To investigate and prove that Aspirin as an antioxidant protects, or at least attenuates Gentamicin ototoxicity in humans. A prospective, randomized, double-blind trial was conducted in 60 patients that completed all requirements. This study was conducted in the Department of Otolaryngology and Orthopedics, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran, between December 2007 and November 2008. The patients were divided into 2 groups, the experimental and the control groups that were similar with respect to gender, age, and weight. The treatment group received 1.5 g/day [500 mg every 8 hours] Aspirin, and the control group received placebo similar to the other group. Comparison of the pure tone audiometry [PTA] at 1000 Hertz [Hz] [p=0.03], 2000 Hz [p=0.003], 4000 Hz [p=0.001], and 8000 Hz [p=0.0010] showed significant differences between mean of PTA at the beginning, 8th, and 15th day. The threshold of PTA at 250Hz was significantly different only at the 8th and 15th day [p=0.004], also at the frequency of 500Hz, the difference between the beginning within 15th day and 8th day with 15th day was significant [p=0.001]. In the present study, we had shown that Aspirin can protect the ototoxic effect of gentamicin in patients