Heterocyclic synthesis with biologically active S-[6-aryl pyridazin 3-yl] thioglycollic acid hydrazides

A number of S-[6-ary1pyridazin-3-yl] thioglycollic acid hydrazides [Ia-c] and thiosemicarbazide derivatives IIa-c have been prepared. 6-Arylpyridazin-3-mercaptomethenyl[4-phenyl--l,2,4-triazolo-5-thiones] [IIIa-c]; 6-arylpyridazin-3-mercaptometheny]-[4-phenyl-l,2,4-triazolo-5-mercaptomethyl ether [IVa]; 6-aryl pyridazin-3-mercaptomethyl-[4-phenyl-I,2,4-triazolo-5-mercaptocyanoethyl] [IVb] and the Mannich bases Va-c have been synthesized from III. The 6-arylpyridazin-3-mercaptomethenyl [5-aminophenyl-l,3-4-thiadiazolines] [VIa-c] and the corresponding 1,3-4-oxadiazoline derivative VII have been synthesized from the phenyl-thiosemicarbazide derivatives IIa-c. The antibacterial activity of the prepared compounds has been screened