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Chinese Journal of Natural Medicines (English Ed.) ; (6): 760-766, 2015.
Article Dans Anglais | WPRIM | ID: wpr-812485

Résumé

In the present study, the effects of Pleurotus nebrodensis polysaccharide (PN-S) on the immune functions of immunosuppressed mice were determined. The immunosuppressed mouse model was established by treating the mice with cyclophosphamide (40 mg/kg/2d, CY) through intraperitoneal injection. The results showed that PN-S administration significantly reversed the CY-induced weight loss, increased the thymic and splenic indices, and promoted proliferation of T lymphocyte, B lymphocyte, and macrophages. PN-S also enhanced the activity of natural killer cells and increased the immunoglobulin M (IgM) and immunoglobulin G (IgG) levels in the serum. In addition, PN-S treatment significantly increased the phagocytic activity of mouse peritoneal macrophages. PN-S also increased the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (INF-γ), and nitric oxide (NOS) in splenocytes. qRT-PCR results also indicated that PN-S increased the mRNA expression of IL-6, TNF-α, INF-γ, and nitric oxide synthase (iNOS) in the splenocytes. These results suggest that PN-S treatment enhances the immune function of immunosuppressed mice. This study may provide a basis for the application of this fungus in adjacent immunopotentiating therapy against cancer and in the treatment of chemotherapy-induced immunosuppression.


Sujets)
Animaux , Mâle , Antinéoplasiques alcoylants , Produits biologiques , Pharmacologie , Utilisations thérapeutiques , Lignée cellulaire , Cyclophosphamide , Immunité , Facteurs immunologiques , Pharmacologie , Utilisations thérapeutiques , Immunosuppression thérapeutique , Interféron gamma , Métabolisme , Interleukine-6 , Métabolisme , Macrophages , Métabolisme , Souris de lignée BALB C , Tumeurs , Traitement médicamenteux , Allergie et immunologie , Monoxyde d'azote , Métabolisme , Nitric oxide synthase type II , Métabolisme , Phagocytose , Pleurotus , Chimie , Polyosides , Pharmacologie , Utilisations thérapeutiques , Facteur de nécrose tumorale alpha , Métabolisme
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