Résumé
Objective To optimize the extraction technology of ferulic acid (FA) in Ligusticum chuanxiong Hort. and tetrahydropalmatine in Corydalis yanhusuo from Kexintong dropping pill. Methods The extraction technology of L. chuanxiong was screened by the orthogonal test. The extration was refined with the high aperture jaffaite. The technology parameter for extracting C. yanhusuo by the classic method of acidic dissolution and alkaline precipitation was optimized by the orthogonal test. Results The more effective way to extract FA from L. chuanxiong was to extract with 12 times amount of 75% alcohol under reflux for 3.5 h. The chuanxiong extract of pH 3 at a flow rate of 5 ml/min on DM-130 macroporous resin column, was eluted with 80% ethanol. The eluent was collected and dried under vacuum. The more effective way to extract tetrahydropalmatine in C. yanhusuo was extracted with 22 times amount of acidic water (pH 4)for 3 h. Conclusion The optimum extraction is reasonable and practicable with high extraction ratio.