Résumé
In this study we describe the occurrence of hematological disorders in bitches with mammary neoplasm and analyze the possibility that alterations present can be used as a diagnostic parameter and prognosis. Two hundred and forty-six dogs with mammary neoplasms (123 with malignant and 123 with benign mammary tumor) and the same number of female dogs without mammary tumors were investigated for observation of hematologic abnormalities. The full blood test and measurement of proteins was carried out before any treatment for breast tumor. The diagnosis of mammary neoplasm was done by histopathology. Few animals with benign tumors had hematological disorders, but in malignant neoplasm the prevalence was 55%, and thrombocytosis, hyperproteinemia (hypergammaglobulinemia) and leucopenia (neutropenia) were the most prevalent abnormalities. Anemia and erythrocytosis had equilibrated occurrence (22 and 21%, respectively). Leukocytosis and thrombocytopenia were less hematologic changes observed. We concluded that because of the high prevalence of thrombocytosis, leukopenia and hyperproteinemia (hypergammaglobulinemia) in bitches bearing mammary tumors, the hematological abnormalities may be signaling of malignant neoplasm.
Neste estudo descrevemos a ocorrência de distúrbios hematológicos em cadelas com neoplasia mamária e sua possível relação com o diagnóstico e o prognóstico. Duzentos e quarenta e seis cadelas com neoplasias mamárias (123 com maligno e 123 com tumor mamário benigno) e o mesmo número de cadelas sem tumores mamários foram investigadas para a observação de anormalidades hematológicas. O exame de sangue completo e mensuração de proteínas foram realizados antes de qualquer tratamento para o tumor de mama. O diagnóstico de neoplasia mamária foi feito por exame histopatológico. Poucos animais com tumores benignos tinham distúrbios hematológicos, mas em neoplasia maligna a prevalência foi de 55%, sendo trombocitose, hiperproteinemia (hipergamaglobulinemia) e leucopenia (neutropenia) as anormalidades mais prevalentes. Anemia e eritrocitose tiveram ocorrência equitativa (22 e 21%, respectivamente). Leucocitose e trombocitopenia foram alterações hematológicas menos observadas. Concluiu-se que, devido à alta prevalência de trombocitose, leucopenia e hiperproteinemia (hipergamaglonulinemia) em cadelas com tumores mamários malignos, tais alterações hematológicas podem ser sinalização para o diagnóstico das malignidades e seu prognóstico.
Sujets)
Animaux , Prévalence , Diagnostic , LeucopénieRésumé
In this study we describe the occurrence of hematological disorders in bitches with mammary neoplasm and analyze the possibility that alterations present can be used as a diagnostic parameter and prognosis. Two hundred and forty-six dogs with mammary neoplasms (123 with malignant and 123 with benign mammary tumor) and the same number of female dogs without mammary tumors were investigated for observation of hematologic abnormalities. The full blood test and measurement of proteins was carried out before any treatment for breast tumor. The diagnosis of mammary neoplasm was done by histopathology. Few animals with benign tumors had hematological disorders, but in malignant neoplasm the prevalence was 55%, and thrombocytosis, hyperproteinemia (hypergammaglobulinemia) and leucopenia (neutropenia) were the most prevalent abnormalities. Anemia and erythrocytosis had equilibrated occurrence (22 and 21%, respectively). Leukocytosis and thrombocytopenia were less hematologic changes observed. We concluded that because of the high prevalence of thrombocytosis, leukopenia and hyperproteinemia (hypergammaglobulinemia) in bitches bearing mammary tumors, the hematological abnormalities may be signaling of malignant neoplasm.