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Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo ; 57(5): 209-216, Sept.-Oct. 2002. tab, graf
Article Dans Anglais | LILACS | ID: lil-325552

Résumé

OBJECTIVES: To determine the presence of immunoglobulin E-rheumatoid factor in patients with juvenile rheumatoid arthritis and to correlate it with clinical and laboratory parameters. METHODS: A multicenter prospective study was carried out from January 1993 to January 1999 with the enrollment of 3 centers of pediatric rheumatology. Ninety-one children with juvenile rheumatoid arthritis diagnosed according to the American College of Rheumatology criteria were studied: 38 (42 percent) with systemic, 28 (31 percent) with pauciarticular, and 25 (27 percent) with polyarticular onset. Ages ranged from 2.1 years to 22.6 years (mean 10.5 ± 4.7), with 59 (65 percent) girls. The control group consisted of 45 healthy children. The detection of immunoglobulin E-rheumatoid factor was carried out utilizing an enzyme-linked immunosorbent assay. Associations of immunoglobulin E-rheumatoid factor with immunoglobulin M-rheumatoid factor (latex agglutination test), total serum immunoglobulin E, erythrocyte sedimentation rate, antinuclear antibody, and functional and radiological classes III or IV were analyzed. RESULTS: Positive immunoglobulin E-rheumatoid factor was found in 15 (16.5 percent) of the 91 children with juvenile rheumatoid arthritis: 7 (18.5 percent) with systemic, 5 (18 percent) with pauciarticular, and 3 (12 percent) with polyarticular onset. A significant correlation was observed between immunoglobulin E-rheumatoid factor and total serum immunoglobulin E in the juvenile rheumatoid arthritis patients. No correlation was found between immunoglobulin E-rheumatoid factor and positive latex agglutination slide test, erythrocyte sedimentation rate, antinuclear antibody, or the functional and radiological classes III or IV in any disease onset group. In 4 out of 45 control children (8.9 percent), immunoglobulin E-rheumatoid factor was positive but with no correlation with total serum immunoglobulin E levels. CONCLUSIONS: Immunoglobulin E-rheumatoid factor could be detected in 16.5 percent of juvenile rheumatoid arthritis patients, particularly in those with high levels of total serum immunoglobulin E, and immunoglobulin E-rheumatoid factor appears not to be associated with disease activity or severity


Sujets)
Humains , Mâle , Femelle , Enfant d'âge préscolaire , Enfant , Adulte , Adolescent , Arthrite juvénile , Immunoglobuline E , Facteur rhumatoïde , Âge de début , Arthrite juvénile , Études cas-témoins , Loi du khi-deux , Test ELISA , Études prospectives
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