Résumé
Objective: Vitamin D has immunomodulatory effects which suggest a possible association between low serum 25-hydroxyvitamin D [25-OH D[3]] levels and autoimmune thyroid diseases. This study was conducted to investigate such a relation between low serum 25-OH D[3] levels and Hashimoto thyroiditis [HT]
Design: Prospective, case-control study
Setting: Internal Medicine Clinic of Sakarya University, Turkey
Subjects: Serum 25-OH D[3] levels were measured in 498 women presented to the outpatient clinic for routine history and physical examination. Thyroid hormones and antibodies were obtained in all patients. Thyroid ultrasonography was performed in antibody positive patients
Intervention: Blood tests and neck ultrasound
Main outcome measures: Vitamin D levels in Hashimoto Thyroiditis
Results: Serum 25-OH D[3] levels were significantly lower in patients with at least one thyroid antibody positive, compared to thyroid antibody negative patients [P = 0.013]. Serum 25-OH D[3] levels were also lower in antithyroglobine [TgAb] positive patients compared to antibody negative patients [P = 0.010]. There was a statistically significant negative correlation between anti-TgAb and serum 25-OH D[3] levels [P < 0.001]. There was no statistically significant difference in serum 25-OH D[3] levels between anti-thyroid peroxidase positive [TPOAb] patients and antibody negative patients [P = 0.643]
Conclusion: Women with HT thyroiditis have lower vitamin D levels compared to women without HT thyroiditis. We determined that serum 25-OH D[3] insufficiency was 1.7 times more likely to be present in patients with HT. This insufficiency may increase the risk of HT disease