An opportunity for testing multiple paternity in a wild Jaguar (Panthera onca) / Uma oportunidade para testar múltipla paternidade em onça selvagem (Panthera onca)

We performed a paternity test for three cubs from one wild female jaguar (Panthera onca). The opportunity for this study was generated by an accident involving a vehicle collision with a pregnant jaguar in the central Amazon. The cubs are polyzygotic triplets and were found to have been sired by the same male. Here, we also provide an overview and discuss several aspects of jaguar reproduction.

Nós realizamos um teste de paternidade em três filhotes de uma onça selvagem (Panthera onca). A oportunidade para este estudo foi criada a partir de um acidente envolvendo a colisão entre um veículo e uma onça grávida na Amazônia central. Os filhotes são trivitelinos e foram gerados por um mesmo macho. Neste estudo nós também oferecemos uma revisão e discutimos aspectos da reprodução de onças.

Clinical assessment of ethinylestradiol and cyproterone acetate in menstrual irregularities of hyper-androgenic origin / Avaliação clínica do uso de duas preparações de etinilestradiol e acetato de ciproterona em menstruação irregular de origem hiperandrogênica

We report on the results of a double-blind, randomized, controlled clinical trial comparing two preparations of ethinylestradiol and cyproterone acetate in the treatment of women of reproductive age presenting menstrual irregularities of hyper-androgenic origin. After obtaining informed consent, subjects were randomized to a 4-month treatment period consisting of one daily dose of 0.035mg ethinylestradiol + 2mg cyproterone acetate. The treatment regimen cycle consisted of one pill, once daily for 21 days, followed by a 7-day pill-free period. We compared the efficacy of two presentations of the drug combination after each treatment cycle (Visits 2, 3, 4, and 5) in establishment and maintenance of menstrual regulation, intensity of menstrual flow, and dysmenorrhea, as well as a comparison of the two presentations in terms of Global Satisfaction and Drug Satisfaction assessments performed by the patients and the investigating physician. At each study visit, drug compliance and use of concomitant medications, as well as incidence, severity and duration of adverse events were recorded. A total of 86 subjects were randomized to treatment, with 43 subjects in each treatment group. At Visit 2 and each subsequent visit, all patients in both treatment groups reported an episode of withdrawal bleeding during the 7-day hormone-free period. We observed a statistically significant (p<0.0001) decrease in the incidence of dysmenorrhea at each study visit in relation to the pretreatment assessment. There was a significant reduction (p<0.0001) in the number of subjects reporting intermenstrual bleeding at each study visit in both treatment groups. Global Satisfaction scores by the patient and physician increased significantly at each successive study visit in both treatment groups. There were no clinically significant changes in vital signs, weight, and body mass index throughout the study period in either group. The number of subjects reporting adverse events at each visit did not vary between treatment groups. The combined oral contraceptive pill containing ethinylestradiol and cyproterone acetate was found to be both effective and safe in the menstrual irregularities of hyper-androgenic origin (amenorrhea, dysmenorrhea, and intermenstrual bleeding) assessed in this study.

Arterite de Takayasu na infância / Takayasu's arteritis

É escrito um caso de Arterite de Takayasu (AT) em uma menina de 3 anos de idade que apresentou hipertensäo arterial e insuficiência cardíca precoces. Säo discutidos o diagnóstico da AT na faixa etária pediátrica