Diffused idiopathic skeletal hyperostosis in a fighting bulldog: a case report

This case report illustrates the presence of diffuse idiopathic skeletal hyperostosis [DISH] in a fighting Bulldog. The dog was referred to the Veterinary Teaching Hospital, University of Agriculture Faisalabad Pakistan, with the presenting complaint of slowly progressing staggering gait, inability to stand on hind limbs and muscle stiffness in lumbo-sacral region. Hematological, serobiochemical and clinical examination were insignificant except presence of extensive new bone formation in the radiograph on the ventral of last 4 consecutive body lumbar vertebras [L4-L8] in lumbar region, running parallel to nuchal ligament. Diagnosis of DISH was made on the basis of clinical signs and radiographical examination which were suggestive of DISH. This report documents the first case of DISH in fighting Bulldog in Pakistan

Evaluation of humoral immunity and protective efficacy of biofilm producing Staphylococcus aureus bacterin-toxoid prepared from a bovine mastitis isolate in rabbit

Mastitis is a one of the major diseases of dairy animals. Staphylococcus aureus is the most common microorganism associated with this dairy scourge. Cure rates of mastitis associated with this pathogen are appallingly low. Biofilm is an important virulence factor and immunogenic structure of S. aureus that makes it resistant to phagocytosis and antibiotics. Reports on the efficacy of vaccine prepared from a biofilm producing S. aureus are infrequent. The present study was designed to evaluate the role of a bacterin-toxoid prepared from a strong biofilm producing S. aureus in effective immunization of rabbits. The strong biofilm producing S. aureus selected from 64 isolates of staphylococci was used to prepare bacterin-toxoid and aluminum hydroxide gel was added as an adjuvant. The vaccine was evaluated in rabbits by challenge protection assay and humoral immune response. The mortality rates in control and vaccinated groups were 80% and 10% at day 7 post challenge and 100% and 20% at day 15 post challenge, respectively. Serum antibody titer [GMT] was significantly higher [294.0] in vaccinated group as compared to control group of rabbits [2.63] at day 45. The results showed that the vaccine has significantly elicited humoral immune response in rabbit and developed protective efficacy against new infections

Octreotride in acute pancreatitis - have it or not?

The study was conducted in the Department of Surgery, Mayo Hospital, Lahore from March 2003 to January 2006. The objective of the study was to see the beneficial effects of Octreotride in acute pancreatitis. Thirty five patients who were diagnosed as acute pancreatitis were divided in two groups. In group A [controlled] Octreotride was given in a dose of 100