Résumé
The aim of this investigation was to study the anti-nociceptive and anti-inflammatory activities of Stauntonia chinensis [S. chinensis] and the possible action mechanisms of effective fractions. The anti-nociceptive and anti-inflammatory activities of S. chinensis extracts, including the 60% EtOH extract [YMG], the n-EuOH extract [YMGB] and the aqueous residue [YMGW] of YMG, and the fractions from YMGB [YMGB1-YMGB7] were investigated by using the mouse acetic acid-induced writhing test and the rat formalin test. The effect of these extracts on the PGE[2] production was tested as well. In the mouse acetic acid-induced writhing test and the rat formalin test, YMGW and YMGB displayed anti-nociceptive and anti-inflammatory activities, suggesting that they were the active ingredients of YMG. Among the fractions isolated from YMGB, YMGB1, YMGB3, YMGB4 and YMGB6 were the main active > ingredients producing anti-nociceptive activity and YMGB3, YMGB5, YMGB6 and YMGB7 were the main active ingredients producing anti-inflammatory activity
Additionally, YMGW, YMGB and its separations reduced the duction of PGE2, which might be the mechanism of them producing anti-inflammatory activity
These results nonstrated the active ingredients of S. chinensis producing anti-nociceptive and anti-inflammatory activities, which is iluable to validate the substance basis of S. chinensis's pharmacological actions