Résumé
Antiinflammatory, analgesic and antipyretic activities of glycosidal fraction isolated from M. chisia were compared in battery of animal tests with known nonsteroidal antiinflammatory drugs (NSAIDs). The pharmacological activities compared favourably with NSAIDs whereas remarkable lack of toxicity was an added advantage.
Sujets)
Animaux , Anti-inflammatoires non stéroïdiens/pharmacologie , Arthrite/traitement médicamenteux , Oedème/traitement médicamenteux , Hétérosides/pharmacologie , Granulome/traitement médicamenteux , Souris , Souris de lignée BALB C , Extraits de plantes/pharmacologie , Rats , Lignées consanguines de ratsSujets)
Abortifs , Alcaloïdes , Animaux , Femelle , Cochons d'Inde , Plantes médicinales , Grossesse , Quinazolines , RatsSujets)
Animaux , Chiens , Évaluation préclinique de médicament , Femelle , Cochons d'Inde , Inde , Mâle , Extraits de plantes/pharmacologie , Plantes médicinales , Lapins , RatsSujets)
Alcaloïdes/pharmacologie , Animaux , Anura , Bronches/effets des médicaments et des substances chimiques , Système cardiovasculaire/effets des médicaments et des substances chimiques , Chiens , Femelle , Cochons d'Inde , Mâle , Souris , Plantes médicinales , Lapins , Rats , Respiration/effets des médicaments et des substances chimiquesRésumé
Embelin, obtained from Embolin ribes was condensed with different primary amines. Depending on the conditions of reaction, disalts or diimines were formed. Ten such disalts and fourteen diimines were developed. Embelin and all its disalts showed analgesic activity whereas all the diimines derivatives were inactive. The disalt, 2:5 disobutyl amine embelin showed maximum action. Analgesic effect was noticed only after intraperitoneal administration but not after subcutaneous, intramuscular or oral administration. The compounds cause some local irritation. The possibility of peritoneal irritation rendering the animals unresponsive to experimental pain seems to deserve consideration. However, analgesic effect could be seen in dogs and cats after intravenous injection. Embelin and its disalt, 2:5 isobutyl amine embelin also exhibited antipyretic and antiinflammatory activities.