Résumé
Thymomas are associated with various autoimmune disorders in adults, most commonly with myasthenia gravis (MG). In MG antibodies developed against acetylcholine (ACh) receptors, resulting weakness of muscle after repeated use and recovery following a period of rest. However, MG due to thymoma is extremely rare in pediatric age group.1We report an infant with MG due to invasive thymoma.
Sujets)
Ponction-biopsie à l'aiguille , Études de suivi , Humains , Immunohistochimie , Nourrisson , Mâle , Myasthénie/complications , Myasthénie/imagerie diagnostique , Myasthénie/thérapie , Appréciation des risques , Indice de gravité de la maladie , Thymectomie/méthodes , Thymome/complications , Thymome/imagerie diagnostique , Thymome/chirurgie , Tumeurs du thymus/complications , Tumeurs du thymus/diagnostic , Tumeurs du thymus/chirurgie , Tomodensitométrie , Résultat thérapeutiqueRésumé
We present two cases where GS was sole presentations, months before the diagnosis of AML.
Sujets)
Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Cytoponction , Moelle osseuse/anatomopathologie , Enfant , Évolution de la maladie , Issue fatale , Humains , Immunohistochimie , Leucémie aigüe myéloïde/traitement médicamenteux , Leucémie aigüe myéloïde/étiologie , Leucémie aigüe myéloïde/anatomopathologie , Mâle , Invasion tumorale/anatomopathologie , Appréciation des risques , Sarcome myéloïde/complications , Sarcome myéloïde/traitement médicamenteux , Sarcome myéloïde/anatomopathologie , Tomodensitométrie , Refus du traitementRésumé
We report a case of systemic onset juvenile idiopathic arthritis (SOJIA), the manifestations of which started with fever and skin rash followed by arthritis within neonatal age. Such presentation is extremely rare in the newborn. After exclusion of closely mimicking conditions like congenital infections, neonatal onset multisystem inflammatory disease (NOMID), neonatal; lupus erythematosus (NLE) diagnosis of SOJIA may be entertained even in a neonate where arthritis, fever and rash are the presenting features.
Sujets)
Arthralgie/diagnostic , Arthrite juvénile/diagnostic , Diagnostic différentiel , Association de médicaments , Exanthème/diagnostic , Fièvre/physiopathologie , Études de suivi , Humains , Ibuprofène/administration et posologie , Nourrisson , Mesure de la douleur , Appréciation des risques , Indice de gravité de la maladie , Stéroïdes/administration et posologie , Résultat thérapeutiqueRésumé
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disorder of the childhood and is manifested by synovitis with or without systemic features. Secondary vasculitis occurring in response to JIA is reflected clinically on different structures or systems of the body. Here is reported a rare case of systemic onset JIA (SOJIA) with vasculitis leading to peripheral gangrene.
Sujets)
Amputation chirurgicale , Antirhumatismaux/usage thérapeutique , Arthrite juvénile/complications , Enfant d'âge préscolaire , Pied/vascularisation , Gangrène/étiologie , Humains , Ibuprofène/usage thérapeutique , Mâle , Prednisolone/usage thérapeutique , Vascularite/étiologieRésumé
Systemic lupus erythematosus (SLE) is a multisystem immunologic disease. Renal and neurological manifestations are frequently seen in childhood SLE. Out of the neurological features movement disorders are uncommon. A case of SLE is presented here with unusual neurological manifestation i.e. chorea associated with microphonia.
Sujets)
Enfant , Chorée/étiologie , Femelle , Humains , Lupus érythémateux disséminé/complications , Troubles de la parole/étiologieRésumé
Two cases of Wilson's disease with unusual features are reported. In one case neurological abnormality was the presenting feature without any clinical involvement of the liver. In the other case, neurologic manifestations were associated with rickets and cholelithiasis, a result of chronic hemolytic state. Apart from clinical profile both the cases were diagnosed by grossly reduced serum ceruloplasmin level. However, Kayser-Fleischer rings were found in each case.