Résumé
Muktashukti bhasma (MSB), an Ayurvedic compound, consisting of pearl, Aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-HT, nystatin and subcutaneous implant of cotton pellets. In all the test procedures the antiinflammatory response of 1000 mg/kg MSB was comparable to the response observed with 300 mg/kg acetylsalicylic acid (ASA). Oral premedication with MSB delayed castor oil-induced diarrhoea in rats, indicating its prostaglandin inhibitory activity. The antiinflammatory activity of the compound is attributed to its ability to cause inhibition of prostaglandins, histamine and 5-HT and also by stabilization of the lysosomal membranes. The antiinflammatory activity of MSB seems one third to half as potent as ASA.
Sujets)
Acide acétique/usage thérapeutique , Aloe/usage thérapeutique , Animaux , Anti-inflammatoires/usage thérapeutique , Association médicamenteuse , Évaluation préclinique de médicament , Femelle , Mâle , Médecine ayurvédique , Phytothérapie , Plantes médicinales , RatsRésumé
Brahmi Rasayan, an Ayurvedic preparation, was studied in rodents for its antiinflammatory effects at po doses ranging between 1 and 10 g/kg. The drug suppressed various experimentally induced inflammatory reactions and did not show any gastric irritation in antiinflammatory doses. It is suggested that it may partially mediate its antiinflammatory activity by interfering with the action and/or synthesis of prostaglandins and also perhaps by stabilization of the lysosomal membranes. Its antiinflammatory activity is comparable to that of indomethacin.
Sujets)
Animaux , Anti-inflammatoires/pharmacologie , Femelle , Mâle , Médecine ayurvédique , RatsRésumé
Glycine (50, 100 and 300 mg/kg), administered daily for 10 days in rabbits challenged with typhoid 'H' antigen and sheep erythrocyte antigen, caused dose- dependent reduction of antibody titre. Inhibition of antibody titre observed with 300 mg/kg was comparable to immunosuppression observed with 1 mg/kg betamethasone.
Sujets)
Tests d'agglutination , Animaux , Production d'anticorps/effets des médicaments et des substances chimiques , Relation dose-réponse (immunologie) , Glycine/pharmacologie , Immunosuppression thérapeutique , LapinsSujets)
Animaux , Anti-inflammatoires non stéroïdiens , Acide acétylsalicylique/pharmacologie , Modèles animaux de maladie humaine , Interactions médicamenteuses , Femelle , Glutamine/pharmacologie , Inflammation/traitement médicamenteux , Mâle , Souris , Lignées consanguines de souris , Douleur/traitement médicamenteux , RatsRésumé
Flupenthixol, a new thioxanthene derivative, was studied for its effects on gastric secretion and gastric ulcers in rats. The compound diminished the volume of gastric secretion, decreased total acid output and protected the glandular gastric mucosa. The observations may be of clinical significance.