Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Acta cir. bras ; 34(9): e201900901, 2019. tab
Article Dans Anglais | LILACS | ID: biblio-1054695

Résumé

Abstract Purpose: To evaluate the effects of tadalafil (TD) in preventing histological alterations of the corpus cavernosum caused by isolated lesions of cavernous nerve (ILCN) and artery (ILCA) in rats. Methods: Fifty male Wistar rats were randomly assigned in five groups: G1: control; G2: bilateral ILCN; G3: bilateral ILCA; G4: ILCN+TD; G5: ILCA+TD. The cavernous bodies were submitted to histomorphometry, immunohistochemistry and biochemical analysis. Results: Nerve density was significantly higher in G2 and G4 compared to control (22.62±2.84 and 19.53±3.47 vs. 15.72±1.82; respectively, p<0.05). Smooth muscle density was significantly lower in G2 and G3 in comparison to G1 (12.87±1.90 and 18.93±1.51 vs. 21.78±1.81, respectively; p<0.05). A significant decrease in the sinusoidal lumen area was observed in G2 compared to controls (5.01±1.62 vs. 9.88±3.66, respectively; p<0.05) and the blood vessel density was increased in G2 and G3 (29.32±4.13 e 20.80±2.47 vs. 10.13±2.71, p<0.05). Collagen density was higher in G3 compared to G1 (93.76±15.81 vs. 64.59±19.25; p<0.05). Conclusions: Histomorphometric alterations caused by ILCN were more intense than those produced by vascular injury, but the collagen analyses showed more fibrosis in animals with ILCA. TD was effective in preventing the majority of the alterations induced by the periprostatic bundle injury.


Sujets)
Animaux , Mâle , Pénis/innervation , Pénis/vascularisation , Agents protecteurs/pharmacologie , Inhibiteurs de la phosphodiestérase-5/pharmacologie , Lésions des nerfs périphériques/prévention et contrôle , Tadalafil/pharmacologie , Pénis/effets des médicaments et des substances chimiques , Pénis/anatomopathologie , Prostatectomie/effets indésirables , Immunohistochimie , Répartition aléatoire , Reproductibilité des résultats , Collagène/analyse , Collagène/effets des médicaments et des substances chimiques , Rat Wistar , Tissu élastique/anatomie et histologie , Tissu élastique/effets des médicaments et des substances chimiques , Dysfonctionnement érectile/prévention et contrôle
SÉLECTION CITATIONS
Détails de la recherche