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1.
The Korean Journal of Internal Medicine ; : 788-790, 2016.
Article Dans Anglais | WPRIM | ID: wpr-76288

Résumé

No abstract available.


Sujets)
Ganglioneurome , Gros intestin
2.
Gut and Liver ; : 79-87, 2014.
Article Dans Anglais | WPRIM | ID: wpr-36649

Résumé

BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We analyzed the immunohistochemical expression of p53, mammalian target of rapamycin (mTOR), c-Met, and insulin-like growth factor 1 receptor (IGF-1R) heat shock protein 70 (HSP70) with the clinicopathologic features of 83 HCCs. RESULTS: p53 expression was higher in the male patients with undifferentiated histological tumor grades, cirrhosis, and portal vein invasion. High 48 c-Met expression correlated with cirrhosis, and high mTOR expression correlated with the tumor grade and cirrhosis. High IGF-1R expression correlated with the tumor grade and cirrhosis. A multivariate analysis identified a significant relationship between the high expression of p53, tumor grade, and portal vein invasion. In addition, a high expression of mTOR was related to tumor grade and cirrhosis, and a high expression of HSP70 was related to portal vein invasion in a multivariate analysis. The Kaplan-Meier survival curve for patients with high versus low Edmondson grades and p53 expression was statistically significant. CONCLUSIONS: p53, mTOR, and IGF-1R expression correlated with the Edmondson tumor grade in a univariate analysis, while p53 and mTOR correlated with the Edmondson tumor grade in a multivariate analysis. In addition, the tumor grade was found to predict survival. p53 was primarily related to the clinicopathologic features compared to other markers, and it is a poor prognostic factor of survival.


Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Carcinome hépatocellulaire/métabolisme , Survie sans rechute , Protéines du choc thermique HSP70/métabolisme , Tumeurs du foie/métabolisme , Pronostic , Protéines proto-oncogènes c-met/métabolisme , Récepteur IGF de type 1/métabolisme , Études rétrospectives , Facteurs de risque , Sérine-thréonine kinases TOR/métabolisme , Résultat thérapeutique , Marqueurs biologiques tumoraux/métabolisme , Protéine p53 suppresseur de tumeur/métabolisme
3.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research ; : 55-59, 2013.
Article Dans Anglais | WPRIM | ID: wpr-143747

Résumé

Extra-pelvic spread of squamous cell carcinoma (SCC) of the cervix to the stomach is extremely rare. We report a case of a 50-year-old woman who presented with dysphagia two years after diagnosis of SCC of the cervix. At esophagogastroduodenoscopy, there was a 1.5x1.2 cm sized ulcero-fungating mass at the cardia portion just beneath the esophagogastric junction which was biopsied for a suspected neoplastic lesion. Histologic and immunohistochemical examinations showed a SCC with characteristics identical to her original tumor from the cervix confirming gastric metastasis. Therefore, we report a case of endocervical SCC with metastatic lesions in the stomach 2 years after the initial diagnosis.


Sujets)
Femelle , Humains , Carcinome épidermoïde , Cardia , Col de l'utérus , Troubles de la déglutition , Endoscopie digestive , Jonction oesogastrique , Métastase tumorale , Récidive , Estomac , Tumeurs du col de l'utérus
4.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research ; : 55-59, 2013.
Article Dans Anglais | WPRIM | ID: wpr-143738

Résumé

Extra-pelvic spread of squamous cell carcinoma (SCC) of the cervix to the stomach is extremely rare. We report a case of a 50-year-old woman who presented with dysphagia two years after diagnosis of SCC of the cervix. At esophagogastroduodenoscopy, there was a 1.5x1.2 cm sized ulcero-fungating mass at the cardia portion just beneath the esophagogastric junction which was biopsied for a suspected neoplastic lesion. Histologic and immunohistochemical examinations showed a SCC with characteristics identical to her original tumor from the cervix confirming gastric metastasis. Therefore, we report a case of endocervical SCC with metastatic lesions in the stomach 2 years after the initial diagnosis.


Sujets)
Femelle , Humains , Carcinome épidermoïde , Cardia , Col de l'utérus , Troubles de la déglutition , Endoscopie digestive , Jonction oesogastrique , Métastase tumorale , Récidive , Estomac , Tumeurs du col de l'utérus
5.
Clinical Endoscopy ; : 91-94, 2013.
Article Dans Anglais | WPRIM | ID: wpr-28643

Résumé

The most common cause of esophagorespiratory fistulas (ERFs) is associated with malignancy. The use of self-expandable metal stents is effective for the treatment of malignant ERFs, but benign ERF is rare, which is why its optimal treatment is not defined yet. There have been few reports describing benign esophagopleural fistula and its treatments in South Korea. Here, we report a rare case of spontaneous esophagopleural fistula, which was successfully treated by endoscopic placement of a membrane covered metal stent.


Sujets)
Fistule , Membranes , République de Corée , Endoprothèses
6.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 38-41, 2013.
Article Dans Anglais | WPRIM | ID: wpr-103774

Résumé

Adenosquamous carcinoma (ASC) is a rare tumor of the liver, which carries a poor prognosis. It has been reported mostly in the form of case studies. Recently, we experienced a case of primary ASC of the liver that has been preoperatively considered as cholangiocelluar carcinoma of the liver. Microscopically, the tumor was composed of adenocarcinoma, squamous cell carcinoma, as well as transitional area, including the transformation of adenocarcinoma to squamous cell carcinoma. The patient remained well with no evidence of post-resection complication or recurrence for 15 month.


Sujets)
Humains , Adénocarcinome , Carcinome adénosquameux , Carcinome épidermoïde , Foie , Pronostic , Récidive
7.
Journal of Korean Medical Science ; : 1835-1838, 2013.
Article Dans Anglais | WPRIM | ID: wpr-9503

Résumé

Previous studies reported that oxaliplatin is associated with sinusoidal obstruction syndrome. However few reports on oxaliplatin induced liver fibrosis are found in the literature. Furthermore pathogenesis of liver fibrosis is not well known. We report a case of 45-yr-old Korean man in whom liver fibrosis with splenomegaly developed after 12 cycles of oxaliplatin based adjuvant chemotherapy for colon cancer (T4N2M0). Thorough history taking and serological examination revealed no evidence of chronic liver disease. Restaging CT scans demonstrated a good response to chemotherapy. Five month after chemotherapy, he underwent right hepatectomy due to isolated metastatic lesion. The liver parenchyma showed diffuse sinusoidal dilatation and centrilobular vein fibrosis with necrosis without steatosis. We could conclude that splenomegaly was due to perisinusoidal liver fibrosis and liver cell necrosis induced portal hypertension by oxaliplatin. In addition, to investigate the pathogenesis of liver fibrosis, immunohistochemical stains such as CD31 and alpha-smooth muscle actin (alpha-SMA) were conducted with control group. The immunohistochemical stains for CD31 and alpha-SMA were positive along the sinusoidal space in the patient, while negative in the control group. Chemotherapy with oxaliplatin induces liver fibrosis which should be kept in mind as a serious complication.


Sujets)
Humains , Mâle , Adulte d'âge moyen , Actines/métabolisme , Antigènes CD31/métabolisme , Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Camptothécine/analogues et dérivés , Traitement médicamenteux adjuvant , Tumeurs du côlon/traitement médicamenteux , Fluorouracil/usage thérapeutique , Hypertension portale/étiologie , Immunohistochimie , Leucovorine/usage thérapeutique , Cirrhose du foie/diagnostic , Tumeurs du foie/secondaire , Composés organiques du platine/administration et posologie , Splénomégalie/diagnostic , Thrombopénie/étiologie , Tomodensitométrie
8.
Korean Journal of Medicine ; : 60-66, 2012.
Article Dans Coréen | WPRIM | ID: wpr-148152

Résumé

BACKGROUND/AIMS: The diagnosis and prognosis of malignant pheochromocytoma are important. Other than distant metastasis, the pathology is insufficient to diagnose malignant versus benign pheochromocytoma. METHODS: We analyzed 33 pheochromocytoma cases using the histological grade on the Thompson and Kimura scales. We compared the Thompson and Kimura scores with the degree of immunohistochemical staining for Ki-67 and heat shock protein 90 (Hsp90). RESULTS: The most frequent symptom was hypertension (17 cases; 51.5%) and four patients had accompanying tumors: one case each of multiple endocrine neoplasm, papillary carcinoma of the thyroid, gastric adenocarcinoma, and neurofibroma. The mean Thompson score was 3.67 in benign pheochromocytoma and 10 in malignant pheochromocytoma, and the Kimura score was 2.17 and 5, respectively. The average immunohistochemical staining for Ki-67 was 5.77 and 10.44 in benign and malignant pheochromocytoma, respectively, while Hsp90 immunohistochemical staining was positive only in the cytoplasm of malignant pheochromocytoma. CONCLUSIONS: Immunohistochemical staining for Ki-67 and Hsp90 was seen in malignant pheochromocytoma. The Thompson and Kimura scales and immunohistochemical results could help to differentiate benign and malignant pheochromocytoma.


Sujets)
Humains , Adénocarcinome , Glandes surrénales , Carcinome papillaire , Cytoplasme , Protéines du choc thermique , Hypertension artérielle , Antigène KI-67 , Métastase tumorale , Neurofibrome , Phéochromocytome , Pronostic , Glande thyroide , Poids et mesures
9.
The Korean Journal of Gastroenterology ; : 386-390, 2012.
Article Dans Anglais | WPRIM | ID: wpr-43461

Résumé

Colloid carcinoma of the liver is very rare, and its clinicopathologic features have not been well characterized yet. We describe herein a case of colloid carcinoma of the liver. Imaging revealed a lobulated mass, measuring 12 cm in diameter at the right lobe of the liver with direct invasion of adjacent peripheral intrahepatic bile ducts. Right hemihepatectomy of the liver was performed according to the possibility of the tumor's malignant behavior. Histopathological examination of the specimen revealed large extracelluar stromal mucin pools containing floating cuboidal to columnar neoplastic cells without ovarian-like stroma. This case seemed to be colloid carcinoma arising in association with intraductal papillary neoplasm of the liver.


Sujets)
Sujet âgé , Femelle , Humains , Adénocarcinome mucineux/diagnostic , Adénomes/diagnostic , Tumeurs des canaux biliaires/diagnostic , Conduits biliaires intrahépatiques , Tumeurs du foie/diagnostic , Imagerie par résonance magnétique , Mucines/métabolisme , Tomodensitométrie
10.
Korean Journal of Medicine ; : 258-263, 2008.
Article Dans Coréen | WPRIM | ID: wpr-89231

Résumé

BACKGROUND/AIMS: Adenomatous polyps of the colon are believed to be precursor of colon cancer. Total polyp resection is indicated when they are identified. However, resection of the polyp is not always attainable at the initial colonoscopy. The aim of this study was to assess the validity of cold biopsy findings as representative of the whole polypectomy specimen, with regard to the histopathological features. METHODS: We analyzed 221 patients with colon polyps that were biopsied at their initial colonoscopy and had their adenomas subsequently removed by polypectomy within 2 weeks from the initial procedure. We analyzed the histopathological discrepancies between the cold biopsy and the polypectomy specimens. RESULTS: We analyzed 302 cases from 221 patients. There was 71.2% agreement between the forceps biopsy and the polypectomy. When colon polyps were diagnosed as carcinoma and villous adenomas, the diagnosis was the same in the polypectomy. Discrepancy between in forceps biopsy with polypectomy was found in the tubular adenomas obtained by forceps biopsy. Fifty tubular adenoma samples obtained by forceps biopsy had a deferent diagnosis than did the polypectomy. Fourteen of 50 tubular adenomas were underestimated by the forceps biopsy samples and seven of the 50 tubular adenomas were finally diagnosed as carcinoma from the polypectomy specimens. Seven villous adenomas were diagnosed as carcinoma and had severe dysplasia (n=4) or 1>=(n=1) size. CONCLUSIONS: Accurate tissue sampling of colorectal adenomas is crucial for their management. However, forceps biopsy does not accurately reflect the histology of colon polyps. Total resection of colon polyps is needed for an accurate diagnosis.


Sujets)
Humains , Adénomes , Adénome villeux , Polypes adénomateux , Biopsie , Basse température , Côlon , Tumeurs du côlon , Coloscopie , Polypes , Instruments chirurgicaux
11.
Korean Journal of Medicine ; : 90-93, 2008.
Article Dans Coréen | WPRIM | ID: wpr-118107

Résumé

Peg-interferon is the main therapeutic agent in patients infected with the hepatitis C virus. It is rather safe, but it is known to induce production of autoantibodies and it can lead to the occurrence of autoimmune disease. Interferon induced thyroiditis is considered a major clinical problem for patients who receive interferon therapy. We recently experienced a 36 year-old woman who developed peg-interferon induced thyroiditis. To the best of our knowledge, this is a rare case report in Korea. We report here on this casea long with a review of the literature.


Sujets)
Femelle , Humains , Autoanticorps , Maladies auto-immunes , Hepacivirus , Interférons , Corée , Glande thyroide , Thyroïdite , Thyroïdite auto-immune
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