Measurement and analysis of dissolved oxygen in circulating water of electromagnetic extracorporeal shock wave lithotripter / 医疗卫生装备

Objective To measure the maximum dissolved oxygen concentration of the lithotripter to avoid visible air bubbles during lithotripsy.Methods The present situation of degassing of lithotripter and clinical requirements for water were introduced.Under the following conditions of 7.5 L water capacity,35 L/h water flow,ambient temperature 28 ℃,17 kV,60 shocks per minute,the lithotripter discharged 10 000 shocks continuously without a visible air bubble in the circulating water,then the dissolved oxygens in the water were measured by using AZ8403 dissolved oxygen meter.The maximum value of dissolved oxygen in the water was determined therefore without a visible air bubble.Results The visible tiny air bubble emerged during lithotripsy if the dissolved oxygen in the water was above 3.37 mg/L and ambient temperature was about 28 ℃;the bubble could be avoided if the dissolved oxygen was under 3.34 mg/L and ambient temperature was about 28 ℃.Conclusion The circulating water with dissolved oxygen concentration less [han 3 mig/L and about 28 ℃ ambient temnperature are recommended for the electromagnetic extracorporea] shock wave lithotripter during lithotripsy.

Experimental research of Fucong Tang improving learning and memory abilities in APP/PS1 double transgenic mice with Alzheimer's disease / 中华神经医学杂志

Objective To investigate the effect of Fucong Tang on learning and memory abilities in A PP/PS1 double transgenic mice with Alzheimer's disease (AD).Methods A total of 20 9-month-old APP/PS1 transgenic mice were randomly divided into two groups:one group receiving Fucong Tang 1 mL/d for 8 weeks (Fucong Tang treatment group) and the other group receiving distilled water treatment.The spatial learning and memory abilities of AD mice were tested with Morris water maze,and Aβ plaques were observed by Aβ+GFAP double immunofluorescence staining,the expression of N-methyl-aspartate (NMDA) receptors subunit 2B (NR2B) by immunohistochemistry,and synapses in CA1 by electron microscopy.Results The 1-4 d escape latency of the Fucong Tang treatment group was significantly shorter than that of the control group (P＜0.005); the time spent in the target quadrants and the frequency of crossing the original platform in the Fucong Tang treatment group were significantly higher than that of the control group (P＜0.05).The average optical density of positive NR2B in the Fucong Tang treatment group was higher that of the control group (P＜0.05).After treatment,Aβ plaques volume and the surrounding activated astrocytes reduced in the Fucong Tang treatment group,while there still presented more compact Aβ plaques and more activated astrocytes in the control group.The damage of synapses of Fucong Tang treatment group presented alleviated.Conclusion Fucong Tang could improve the learning and memory abilities of AD mice by reducing compact Aβ plaques and alleviating associated toxic effects on neurons,and further promoting the expression of NR2B and improving synapse structure.

Distribution of the intermediate hosts of Echinococcus multilocularis in Shiqu County, Sichuan, China / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>The rodentia and lagomorpha animals are the intermediate hosts of Echinococcus multilocularis, their distribution and infection of this parasite may facilitate the infection of definitive hosts such as dogs. The aim of this study was to determine the distribution of the intermediate hosts of Echinococcus multilocularis in Shiqu County, Sichuan, China.</p><p><b>METHODS</b>A systematic sampling method was used to investigate the density of burrows of rodents and lagomorphs at 97 pasture sites in winter and summer pastureland and remote sensing (RS) technology was used to correlate their densities to the distribution of these animals in different landscape types.</p><p><b>RESULTS</b>Based on the densities of Ochotona curzoniae, Microtus fuscus (dependent variable) and their burrow densities (independent variable) in survey points, regression equations were fitted respectively (Ochotona curzoniae, P < 0.0001, R(2) = 0.8705; Microtus fuscus, P < 0.0001, R(2) = 0.9736). Their burrow density in summer pastureland was higher than in winter pastureland (F = 36.65, P < 0.0001). The burrow densities of Ochotona curzoniae and Microtus fuscus in bareland and half-bareland are higher than in grassland (F = 7.73, P < 0.001).</p><p><b>CONCLUSIONS</b>The regression relationship between the densities of Ochotona curzoniae and Microtus fuscus and their burrow densities indicate that the burrow densities could reflect the animal densities and that the burrow density was greater in summer pastureland than in winter pastureland. The main distribution areas of the intermediate hosts were in bareland and half-bareland.</p>

Fleas notified on Microtus fuscus foci in Sichuan province / 中华流行病学杂志

Objective To analyzed the variant information on the indices regarding fleas from natural foci of Microtus plague in Sichuan epidemic area during 2000 to 2008.Methods Statistical and analytical methods were used on the surveillance data regarding Microtus fuscus plague.Results There were 19 flea species identified and the share of Callopsylla sparsilis was 62.79 percent while the share of Amphipsylla tuta tuta was 30.90 percent on Microtus fuscus plague.The infection rate of fleas and the flea index were the highest in October and the lowest in December and March.Species as Callopsylla sparsilis,Amphipsylla tuta tuta and Rhadinopsylla dahurica vicina could naturally infect the Yersinia pestis.Conclusion Microtus fuscus plague could become epidemic when animals and flea species were infected.We should emphasis on plague monitoring program so as to prevent the occurrence of the disease.

Best target position and range of lesion for magnetic resonance image -guided stereotactic cingulotomy / 中华神经医学杂志

Objective To explore the best target position and range of lesion for magnetic resonance image (MRI)-guided stereotactic cingulotomy. Methods We retrospectively analyzed the data of 71 patients underwent MRI-guided stereotactic cingulotomy, including 7 with chronic pain and 64 with psychiatric disorders. The cingulate gyrus target chose were 5 mm as X, 10-20 mm posterior tip of the lateral ventricle as Y, 2 mm above the roof of the lateral ventricle as Z. The target position and range of lesion were determined and revised by routine sagittal, axial and coronal stereotactic MRI scans. Radiofrequency thermocoagulation lesions were produced by inserting an electrode (1.6 mm diameter and 4 mm uninsulated tip) and heating them at a temperature of 75℃ for 100 seconds with a volume of lesion reaching 15 mm×10 mm×10 mm. Early postoperative MR or CT scans and long-term followed up examination were available for all cases. Results Postoperative images showed that the lesions were all in the anterior cingulate gyrus. Two patients reported transient urinary incontinence without permanent complications; significant pain relief appeared in all patients with chronic pain; In 64 with intractable psychiatric disorders, cure was showed in 3 obvious improvements in 35, improvement in 22, and no change in 4. Conclusion MRI-guided stereotactic cingulotomy offers substantial advantages by allowing direct visualization of the cingulate gyrus and surrounding structures and the best range of lesion is 10-25 mm from the anterior point of the corpus callosum, 10 mm above the bottle of cingulate gyrus and 10 mm in width.

Monitoring the Microtus fuscus plague epidemic in Sichuan province during 2000-2008 / 中华流行病学杂志

Objective To analyze the epidemic tendency of Microtus fascus plague during 2000-2008 in Sichuan province. Methods To investigate the plague each year according to "overall Plan of the Plague in the Whole Nation" and "Surveillance Program of Sichuan Province Plague". Results There were plague epidemic from 2000 to 2008, with the average density as 312.41/ha. 42.57% of the Microtus fuscus were infected by body Fleas. The Fleas Index was 0.88 and the Index for nest Fleas of Microtas fuscus was 55.89. Six kinds of animals were infected by not only the Microtus fuscus but also herd-dog, sand fox, Tibetan sheep, domestic cats and Cricetulus longicaulatus as well. The positive rate of live Microtus fuscus was 0.32% but 22.99% in the dead Microtus fuscus. The overall positive rate on serological test was 6.70%. There were 4 Sections, 11 species and 19 kinds Fleas identified and carrying 3 kinds of fleas, Callopsylla sparsilis, Amphipsylla tntua tutua and Rhadinopsylla dahurica vicina, with the overall infection rate as 0.054%. Conclusion Plague among Microtus fuscus showed a continuous epidemic in Sichuan province during 2000-2008.