Résumé
Objective To compare the effect of dopamine and norepinephrine in the treatment of shock and the effect on renal function.Methods 100 shock patients were randomly divided into norepinephrine group and dopamine group,50 cases in each group.On the basis of other anti-shock treatment,norepinephrine or dopamine was used in group A and group B.The mortality of the 7th day and urea nitrogen(BUN),creatinine values (CRE) 12h,72h after treatment were observed.Results There was no significant difference between two groups in the 7th day mortality (x2 =0.765,P ＞ 0.05).However,the proportion of arrhythmia in dopamine group was 34％,which was significantly higher than the norepinephrine group(16％) (x2 =3.84,P ＜ 0.05).After treatment,the BUN and CRE levels in both two groups recovered,the norepinephrine group recovered better than the dopamine group (P ＜ 0.05).Conclusion Norepinephrine and dopamine in the treatment of shock has similar clinical effect,but norepinephrine is more effective in the improvement of renal function compared with dopamine.
Résumé
Objective:To investigate the expression of Oct4 and Wnt2 in human glioma tissues and its relationship with the clinicopathological features of glioma. Methods: Fifty-six paraffin blocks were obtained from glioma patients receiving surgery. The diagnosis of these patients were confirmed by pathology in our hospital from 2006-2009. Immunohistochemi-cal staining was used to examine Oct4 and Wnt2 expression in the brain tissues of 10 patients with acute brain injury and 56 glioma tissues (including 15 recurrent cases). Results: The normal brain tissues were negative of Oct4, with only one case showing weak Wnt2 expression. Thirty-four of the 56 glioma tissues showed positive expression of Oct4 (60.7%), and 40 showed positive expression of Wnt2 (71.4%). Positive expression rates of Oct4 and Wnt2 in low-grade and high-grade glioma tissues were 46.2 %, 73.3% and 57.7 %, 83.3%, respectively (P < 0.05). Oct4 positive rates in the recrudescence and newly diagnosed glioma tissues were 86.7% and 51.2%, respectively (P < 0.05). Oct4 expression in the glioma tissues was positively correlated with that of Wnt2 (r = 0.537, P < 0.01). Conclusion: Expression of Oct4 and Wnt2 is associated with the malignant degrees of glioma, and Oct4 expression is related to the recurrence of glioma. Oct4 might participate in the development and progression of brain glioma through Wnt signaling pathway.