Résumé
To investigate the efficacy of high-dose methylprednisolone pulse therapy in the treatment of Enterovirus 71 [EV71] encephalitis. To determine whether high-dose methylprednisolone pulse therapy should be used, 80 cases of pediatric patients with EV71 encephalitis were randomly divided into steroid pulse therapy group and non-steroid pulse therapy group and their clinical information was compared using statistic analysis. There was no statistical difference in the duration of fever, duration of nervous system involvement, duration of hospital stay, blood pressure, and cure rates between the two groups [p>0.05]. The heart rate, respiratory rate, white blood cell counts and blood glucose of the steroid pulse therapy group were significantly higher than those of the non-steroid pulse therapy group [p<0.05]. Highdose steroid pulse therapy to treat EV71 encephalitis can't shorten the course or improve the prognosis of the disease. In contrast, it has side effects and might aggravate disease condition or interfere with disease diagnosis. Our study suggested that there is no beneficial effect to use high-dose steroid pulse therapy for the treatment of EV71 encephalitis
Résumé
A novel fluorescent switch was constructed based on poly 3-{[ 1-( 2-hydrazino-2-oxoethyl ) piperidin-4-ylidene] methyl}thiophene ( PMTH ) in the presence of Pb2﹢ or S-adenosylmethionine ( SAM ) . The switch turned off in the presence of Pb2﹢owing to complex effect, and the fluorescence intensity of PMTH solution was efficiently quenched by Pb2﹢ ions. Upon adding SAM to the Pb2﹢-PMTH solution, which was stronger Pb2﹢ chelators, it could form more stable SAM-Pb2﹢, the Pb2﹢ ion was displaced from PMTH and the fluorescence of PMTH was recovered. By triggering the turn-on signal of PMTH, a new discrimination ability toward SAM method for the determination of SAM was established. The effects of the interaction on the fluorescence spectral characteristics of these Pb2﹢-PMTH and Pb2﹢-SAM complexes in H2 O-CH3 CH2 OH(4:1, V/V) solution, suitable reaction conditions and influencing factors were investigated. This method offered good sensitivity and selectivity for detecting SAM in the presence of amino acids and metal ions. Under optimum conditions, the concentration of SAM in the range from 1. 0 × 10-8-2. 0 × 10-6 mol/L exhibited a linear relationship with the relative fluorescence intensity. The regression equation was △I = 68. 51﹢72. 32c (μmol/L), the correlation coefficient r=0. 9982. The limit of detection was 8. 72×10-9 mol/L. The system was successfully applied for detecting SAM in human serum, urine and injection samples.
Résumé
The experiment method of "Liquid-vapor" permeation for nitro oxidizer's skin protective materials by the indicator of pH test paper is developed,and the method for cankerous testing and evalution roles are confirmed too.The result of the experiment shows that butyl rubber and halogenated butyl rubber have better protective performances for "liquid-vapor" permeation of nitro oxidizer,while fluorine rubber,polyethylene and polyterafluoroethylene have better cankerous protection capabilities.
Résumé
Objective To explore the method of permeability for skin protective materials of rocket propellant based on the design and make of sealing container. Methods The propellant mass permeated per minute and per square centimeter was calculated by testing the mass through the sample at the fixed time in the sealing container. Results The method of permeability for skin protective materials against rocket propellant was developed by the mass variation of propellant in the sealing container. The limits of 100?g /(cm2?min) was raised to assess if the material had the protection ability. In the meantime, the reliability of material protection behavior was improved. Conclusion The science of the method developed is confirmed by comparing the permeation performance of protection materials at home and abroad, and the method can be the basis to assess the ability of protection materials.