Expression of EphB4 in non-small cell lung cancer and clinical significance / 吉林大学学报(医学版)

Objective To investigate the expression patterns of EphB4 in non-small cell lung cancer(NSCLC) and evaluate their roles in tumor initiation and development.Methods The expressions of EphB4 were detected with immunohistochemical method in 34 cases of NSCLC and 16 cases of adjacent normal lung tissues.Results The positive expression rate of EphB4 in NSCLC was 41.2%(14/34).The expression of EphB4 in 16 cases of adjacent normal lung tissue were all negative,there was significant difference between them(P0.05).Conclusion EphB4 may play a key role in carcinogenesis and progression of NSCLC.