Neural circuit mechanisms in mesolimbic reward system underlying opioid addiction / 中国药理学通报

Opioid addiction has high incidence and does great harm to individuals and society. The mesolimbic reward system plays an important role in opioid addiction. Previous studies have focused on functional adaptations in specific brain regions of the mesolimbic reward system, but the neuronal interactions in mesolimbic reward system underlying opioid addiction remain unknown. The paper reviews the neural circuit mechanisms in mesolimbic reward system involved in opioid addiction, in order to provide a broader vision for understanding the mechanisms of opioid addiction.