Effects of semelil [ANGIPARS[TM]] on focal cerebral ischemia in male rats

Cerebral ischemia is one of the main causes of long term disability and death in aged populations. Many herbal drugs and extracts have been used for the treatment of cerebral ischemia induced insults. This study was designed to investigate the protective effect of Semelil [ANGIPARS[tm], a new herbal drug, on focal cerebral ischemia in male rats. Male rats were divided into five groups: sham-operated, ischemic animals treated with distilled water as vehicle, ischemic animals treated with 1.10 and 100 mg/kg of Semilil respectively. Middle cerebral artery occlusion [MCAO] model was used in NMRI rats and neuronal injury analyzed in hippocampal CA1 sector after 48 hrs of Middle Cerebral Artery [MCAO]. Results of this study showed that treatment with semelil attenuated ischemic damages and has positive effects on focal cerebral ischemia

[Effects of Morphine dependency on the ovarian folliculogenesis following superovulation in mice]

Opioids may affect hypothalamic GnRH secretion and Hypothalamic-Pituitary- Gonad axis, resulting in reproductive disturbances. Current study investigates the effects of morphine on structure of ovary following superovulalion through morphologic/morphometric studies. Twelve young female NMRI mice were allocated into treatment and control groups. Treatment group received oral morphine at final dose of 0.4mg/ml for 21 days. Physical dependency was proved by injection of naloxone [2mg/kg ip]. The mice were superovulated by 10 iu PMSG [ip] and 48 hours later were sacrificed by cervical dislocation. Ovaries were removed and H and E staining was done. Every 10[th] serial section, which represents nonrandom 10 percent sample was counted. Follicles were classified into small, growing, antral and atretic according to the diameter and number of follicular cell layers surrounding oocytes. The volume and the weight of ovaries were recorded. In addition, the diameter of the antral follicles and oocytes was carefully measured by a calibrated oculometer. The volume and the weight of ovaries showed no significant alterations in the two groups. The proportion of small and atretic follicles was statistically different in treatment and control groups [P<0.001]. According to our data, oral morphine did not alter the volume and the weight of the ovary. However, folliculogenesis was moderately affected by morphine and following superovulation the behavior of ovaries in the treatment group is comparable to the control group