Effect of choloroquine on the serum concentrations of glucose and lipids in rats fed on high fat diet

This study is carried out on 35 rats divided into 4 groups. Group I [control]; fed on balanced diet for 4 weeks, group II; fed on high fat-diet for 4 weeks and injected chloroquine I.P 5 mg/kgm 4 times daily in the last 3 days, and group IV; fed on high fat-diet for 4 weeks and injected chloroquine in the last 3 days. At the end of the food regimen, rats were killed and the blood was analyzed for glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. Chloroquine injection produces no significant changes in the serum level of glucose and lipids in rats fed on balanced diet but, it lowers significantly the elevated serum concentrations of glucose, cholesterol, and LDL-cholesterol in rats fed on high fat-diet