Synthesis and fungicidal activity of some new imidazoles from 2-[chloromethyl]-1H-benzimidazole

A series of substituted 2-thiomethylbenzimidazoles 2-4, 2-phenoxy-methylbenzimidazoles 5 and 2-aminomethylbenzimidazoles 6 and 7 were synthesized by reactions of 2-chloromethylbenzimidazole 1 with dithiocarbamate, pyrirnidine-2-thiols, phenol derivatives as well as primay aromatic and heterocyclic amines, respectively. Most of the synthesized compounds were screened for their antifungal activity against Botrytis sinerea, Fusarium, solani and Rhizocionia solani fungi. Some of the tested compounds showed 100% inhibition for the fungal growth at concentration ranges from 200-1000 ppm

Synthesis and chemoprophylactic effect of novel coumarin derivatives

A series of coumarin derivatives carrying different biologically active side chains and heterocyclic substituents were synthesized from 8-acetyl-4-methyl-7-hydroxycoumarin. Among these side chains are alkylamino, semicarbazono- and N[4]-substituted thiosemicarbazonoethyl, I-hydrazonoethyl and substituted I-hydroximinoethyl groups, while heterocyclic substituents were derived from pyran, oxadiazole, thiadiazole and thiazolidinone rings. Also, some derivatives of pyrano [2,3-h]chromen-9-carbaldehyde were synthesized. Some of these new products were studied for their chemoprophylactic effect in Schistosoma mansoni infected mice