Possible Association between -G308A Tumor Necrosis Factor-alpha Gene Polymorphism and Major Depressive Disorder / 신경정신의학

OBJECTIVES: The present study was to examine possible association between the -G308A tumor necrosis factor (TNF)-alpha gene polymorphism and major depressive disorder (MDD) in Korean. METHODS: 108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Genotype and allele distributions in patients with MDD (p=0.02, p=0.01, respectively), were significantly different from those of the controls. CONCLUSION: The present study suggests that the -G308A TNF-alpha gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.