Antimalarial drug quality monitoring in 2007

Background: Monitoring antimalarial drug quality should be conducted regularly in locals to enhance the effect of treatment for malaria \r\n', u'Objective: to study and analyze antimalarial drug quality\r\n', u'Subjects and methods: The study was carried out in 2007 for 5 provinces supported by the Global Fund: Ha Giang, Dien Bien, Thanh Hoa, Quang Tri and Gia Lai. Material were malaria drugs: artesunat, chloroquin, quinine, mefloquin, fansidar\u2026etc\r\n', u'Results and conclusion: The strict supervision on the anti-malarial drug quality by the National Malaria Control Program was very good and no substandard antimalarial drugs were detected. Evaluation of antimalarial drug quality and control was made for finding out the counterfeit drugs through sentinel sites in both private and public sectors. A total of 268 samples were collected, of which 13 samples were found substandard drugs (8 samples collected in private and 5 samples in public sectors). No counterfeit drugs were found. \r\n', u'

Study on evaluation of a schedule for treatment of malaria in children and adult based upon some pharmacokinetic parameters and clinical effects

A compartment model with separate pharmacokinetic estimates for children and adults was found best to describe the disposition of artemisinin after oral administration. The popular estimates for artemisinin half life and clearance and distribution volume were found for both age groups. The concentration was estimated decrease from day 1 to day 5, a value found to be similar for children and adults. Clinical efficacy, in terms of parasite clearance and fever subsidence times, was comparable between children and adults no difference