Relationship between leukocyte count, erythrocyte sedimentation rate, blood pressure, body mass index, and type 1 diabetes mellitus

Emerging data suggest that diabetes mellitus [DM] [type 1 and type 2] may play a role in the increasing level of leukocyte [WBC] count and erythrocyte sedimentation rate [ESR]. Because of few prospective studies have addressed this issue, this study examined the relation between DM type 1 and the total, differential leukocyte count, ESR, body mass index [BMI], and systolic blood pressure [SBP] and diastolic blood pressure [DBP] for 228 participants: 78 men and 150 women have been measured. Among 78 men, there are 21 diabetic [13 below 40 years old] and among 150 female subjects, 33 develop diabetes [18 below 40 years old]. Smoking status has no real effect in the present data. All data were collected from Central Tripoli Hospital and Yefren Hospital. In male but not female DM type 1 showed significant [p<0.05] effect on the total WBC count and the percentages of differential WBC [lymphocytes% and neutrophils%] compared with the normal group. However, BMI and ESR were found to be significantly [p<0.05] effected by DM type 1 in both genders. These findings are consistent with the hypothesis that an activation of leukopoiesis may play a role in pathogenesis of DM

Ultrastructural study of the effect of inhalation of mosquito-coil smoke on the interalveolar septum of the lung of rat

Smokes of mosquito coils are used daily to control mosquitoes during summer season in subtropical and tropical countries. So, the aim of this study was to evaluate the effect mosquito coils smokes on the fine structures of the interalveolar septum of the lung of rat. A prominent effect has been observed in the interalveolar septum of lungs of 25 male rats that were exposed to mosquito-coil smokes with d-allethrin at airborne particles concentration of 1.27 mg/m3, 7 hrs. /day, 7 days/week for 3 months. In addition to another group of air exposure animals as a control group. Marked hypertrophy and proliferation of disorganized type II alveolar cells with apical microvilli were found to contain numerous vacuolated lamellar bodies. The presence of numerous extravasated red blood cells in the interstitial and alveolar spaces indicates that transient separations of cell junctions of endothelial cells of capillaries to get out blood corpuscles and platelets leading to haemorrage and consequently clotting. Increased frequency of alveolar macrophages, in addition to, the presence of neutrophil and plasma cells are characteristics of these inflammatory processes. The interalveolar septum had been increased in thickness due to proliferation of myofibroblasts and a prominent increase in collagen synthesis

Ultrastructural changes of the renal tubular cells and hepatocytes of neonatal rats suckled milk from mothers subjected to subchronic toxicity of cadmium chloride

Neonatal off springs from female rats administered cadmium chloride by the oral route [0.5 mg.kg[-1]. day[-1] throughout their entire gestation and lactation periods. The pups were nursed their mothers until they weaned at the age of 28 days. At the end of the experiment, neonatal rats were anaesthetized by ether, then dissected and liver and kidney tissues were rapidly removed and processed for transmission electron microscopic examination. The uItrastructural observations of the proximal convoluted tubules were the absent of the apical microvilli, basal striation and endocytotic-lysosomal apparatus. Meanwhile hepatocytes showed few, sporadic mitochondria in concomitant with ill developed rough and smooth endoplasmic reticula. In addition to the apoptosis of hepatocytes. In conclusion, cadmium was transmitted via milk to the rat pups and potentially toxic to proximal convoluted tubular cells and to less extent to hepatocytes with multifactor mechanisms of cadmium toxicity