Nasal polyposis: immunohistochemical study [a hypothesis for their development]

Nasal polypi and turbinates were obtained from individuals undergoing surgery for symptomatic nasal obstruction caused by nonspecific rhinosinusitis or allergic rhinosinusitis. Monoclonal antibodies were used to identify macrophages, lymphocytes and plasma cells. Middle turbinates and polyps had more macrophages, lymphocytes, plasma cells and eosinophils than the inferior turbinates. A theory for the pathogenesis of nasal polyps was proposed. Local release of inflammatory mediators could cause sodium absorption and chloride permeability to be higher in polyps than in normal turbinate epithelium

Study of Ki 67 antigen expression in some fibrohistiocytic fumours

This study was done on four cases of fibrohistiocytic tumors, two benign fibrous histiocytoma and two malignant storiform fibrous histiocytoma. It was believed that growth fraction with Ki 67 increased relatively and respectively with the advanced steps of tumor progression which were generally characterized by an increased growth fraction with neoplastic cell population. This work aimed to study the growth fraction determined with Ki 67 antigen in some fibrohistiocytic lesions

P53 expression in phylloides tumours

This work was done on seventeen cases of phylloides tumors of the breast [ten benign, five borderline and two malignant]. P53 expression was studied using peroxidase method showing abnormalities in a minority of borderline and malignant tumors