Progress of vascular endothelial growth factor and the tubulointerstitial injury / 国际儿科学杂志

Vascular endothelial growth factors (VEGF) are cytokines that leading to endothelial cell differentiation,proliferation,migration,and increase vascular permeability,which take part in the pathological process of microvascular.Recent studies have found that VEGF have close relationship with tubulointerstitial pathological changes.VEGF take part in the renal interstitial extracellular matrix synthesis and degradation.Therefore,we take more attention to the important role of VEGF in renal tubular damage.The present review will outline the current understanding of VEGF in the tubulointerstitial injury.