RÉSUMÉ
Background: Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion, often accompanied by hypercholesterolemia. Metformin is a first-line antihyperglycemic drug that is often combined with other antihyperglycemic drugs. Purple sweet potato leaves have been widely studied to reduce glucose and cholesterol levels. Methods: This study was an experimental study using rats induced with a high-fat diet and streptozotocin, which were divided into 8 treatment groups, namely groups given CMC Na 0.5%, Metformin 45 mg/kg BW, Purple Sweet Potato Leaf Extract (SPLE) 200 mg/kg BW, SPLE 400 mg/kg BW, SPLE 800 mg/kg BW, SPLE 200 mg/kg BW with metformin 45 mg/kg BW, SPLE 400 mg/kg BW with metformin 45 mg/kg BW, and SPLE 800 mg/kg BW with metformin 45 mg/kg BW. Results: After treatment for 28 days with SPLE doses of 200 mg, 400 mg, and 800 mg/kg BW, both single doses and combinations with metformin showed a decrease in fasting blood glucose levels and total cholesterol, which were statistically significantly different (p<0.05) between treatment groups using the one-way ANOVA. The combination of SPLE 800 mg/kg BW with metformin normalized blood glucose levels of 93.50±4.93 mg/dl. Conclusion: The combination of purple sweet potato leaf extract with metformin is more effective in reducing blood glucose and total cholesterol levels compared to the single administration of metformin and SPLE.
RÉSUMÉ
Background: The bandotan plant has been officially recognized by the world health organization (WHO) as a traditional medicinal medicine. The Chinese government has officially recognized the bandotan plant as having health-promoting and longevity-enhancing properties. The content of several secondary metabolites of this bandotan plant, such as alkaloids, tannins, flavonoids, glycosides, and saponins, makes this plant have significant potential as an alternative to traditional therapy. This research aims to evaluate the bactericidal efficacy of the ethanol extract derived from the bandotan herb against Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa bacteria. Methods: The test was conducted using agar diffusion and streaking methods, with the test sample concentration being taken into account. The test results demonstrated that the ethanol extract of herba bandotan, at a dosage of 300 mg/mL, possesses inhibitory effects on the development of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa bacteria. Results: The concentration required to kill Staphylococcus aureus bacteria by 50 mg/mL is achieved with a percent reduction of 98.27%. Similarly, a concentration of 75 mg/mL is needed to kill Pseudomonas aeruginosa bacteria with a percent reduction of 96.36%. Lastly, a concentration of 100 mg/mL can effectively eliminate Staphylococcus aureus bacteria with a percent reduction of 99.24%. Conclusions: The study's findings indicate that the ethanol extract derived from the bandotan plant had bactericidal and bacteriostatic properties against Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa bacteria.