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1.
J Cancer Res Ther ; 2008 Jul-Sep; 4(3): 137-9
Article Dans Anglais | IMSEAR | ID: sea-111561

Résumé

An eleven-year-old boy presented with a swelling in his left elbow. Radiologically the features were that of an Ewing's sarcoma involving the ulna. Histopathology showed small round cell tumor strongly positive for Monoclonal Imperial Cancer research fund 2 (MIC2) antigen. Similar cells in the bone marrow were involved with MIC2 positivity. The patient developed skin lesions, which on biopsy were found to be chloromas. The initial biopsies were reevaluated with special stains revealing granulocytic sarcomas in acute myeloid leukemia masquerading as Ewing's due to its MIC2 positivity. The possibility of myeloid neoplasms should be considered routinely with known MIC2 positive round cell tumors.


Sujets)
Enfant , Diagnostic différentiel , Coude/anatomopathologie , Cytométrie en flux , Humains , Leucémie aigüe myéloïde/métabolisme , Mâle , Sarcome d'Ewing/anatomopathologie , Sarcome myéloïde/métabolisme , Marqueurs biologiques tumoraux/analyse
2.
J Cancer Res Ther ; 2008 Jan-Mar; 4(1): 18-20
Article Dans Anglais | IMSEAR | ID: sea-111425

Résumé

BACKGROUND: Until very recently mantle field radiotherapy remained the gold standard for the treatment of favorable early-stage Hodgkin's lymphoma. The classic mantle includes all the major lymph nodes above the diaphragm and extends from the inferior portion of the mandible to the level of the insertion of the diaphragm. AIMS: To describe a simple technique that has been devised to treat the mantle field with the help of multileaf collimator and using computed tomography (CT)-based treatment planning. MATERIALS AND METHODS: CT scan was performed with the patient in the supine position and the datasets were transferred to the Eclipse treatment planning system. Elekta Precise linear accelerator equipped with 40 pairs of multileaf collimator (MLC) was used for the execution of the mantle field. The MLC's shapes were designed to take the shape of the conventional customized blocks used for treatment of mantle field. The anterior mantle field was divided into three separate MLC segments with the collimator kept at 0 degrees. The first MLC segment was shaped to cover the neck, clavicular regions, and mediastinum. The second and the third MLC segments covered the right and left axilla, respectively. The posterior fields were opposed to the anterior subfields in a similar fashion. The dose was prescribed at the midplane, using reference points. RESULTS AND CONCLUSION: The technique described in this study is very simple, easy to implement, and avoids unnecessary delay in the execution of the mantle field. The mantle field can be easily shaped with the multileaf collimators, without any collimator rotation.


Sujets)
Maladie de Hodgkin/imagerie diagnostique , Humains , Radiothérapie/instrumentation , Tomodensitométrie
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