1.
Indian J Physiol Pharmacol
;
1979 Oct-Dec; 23(4): 386-8
Article
Dans Anglais
| IMSEAR
| ID: sea-106750
Sujets)
Animaux , Amines biogènes/physiologie , Encéphale/physiologie , Hypothalamus/métabolisme , Mâle , Mélatonine/pharmacologie , Mésencéphale/métabolisme , Neurones/physiologie , Norépinéphrine/métabolisme , Glande pinéale/physiologie , Axe hypophyso-surrénalien/physiologie , Rats , Sérotonine/métabolisme
2.
Indian J Physiol Pharmacol
;
1976 Oct-Dec; 20(4): 216-20
Article
Dans Anglais
| IMSEAR
| ID: sea-108987
Résumé
The hypotensive drug alphamethyldopa, an inhibitor of serotonin synthesis, caused significant hypothermia ranging from 33.4 to 34.8 degrees C (t=3.09 at P less than 0.05) in four out of nine hypertensive patients, with evidence of cerebral atherosclerosis. The anti-serotonin effect of alphamethyldopa correlated with statistically significant (t=6.8 at P less than 0.001) fall in the 24 hour urinary 5-hydroxyindoleacetic acid on the third day of the therapy. The possible mode of hypothermic side effect is discussed.