Utility of radius bone densitometry for the treatment of osteoporosis with once-weekly teriparatide therapy

OBJECTIVES: As clinics that treat patients with osteoporosis do not usually have central dual-energy X-ray absorptiometry (DXA), bone density is often measured with radial DXA. However, no long-term evidence exists for radius bone density outcomes following treatment with once-weekly teriparatide in actual medical treatment. METHODS: We evaluated changes in bone density at 6-, 12-, and 18-month intervals using radial DXA in patients treated with once-weekly teriparatide for more than 6 months. RESULTS: A significant increase in bone mineral density (BMD) was observed at the 1/3 and 1/10 radius sites 12 months after the initiation of once-weekly teriparatide. We also observed that the rate of change in BMD was greater at the distal 1/10 radius than at the 1/3 radius. CONCLUSIONS: Considering these points, the effect of once-weekly teriparatide therapy can be observed at the radius. In clinics that do not have central DXA, but instead have radial DXA, these findings can help to evaluate the effect of once-weekly teriparatide treatment on osteoporosis.

EVALUATION OF SCUBA DIVING WORK LOAD / 体力科学

Divers' heart rates were measured under real ocean diving conditions with the purpose of evaluating the workload during SCUBA diving. For the subjects, all-out tests were conducted and evaluated in each of the following conditions: 1. ergometer cycling, 2. ergometer cycling using diving regulator, 3. fin-swimming in a swimming pool with diving equipment. No significant heart rate difference was found between the pre-dive and post dive of each subject; although, in novice divers, high heart rates such as 140/min or more were observed especially during the dive gear wearing phase on the topside and/or floating on the surface phase, suggesting there should be some high heart rate inducing factors, other than the exercise, like stress. Whereas, in the results of the all-out tests, the heart rate for fin-swimming was 16~18 beats/min lower, as well as 5.7~14.2 ml/kg/min lower for VO₂max, as compared to the ergometer cycling. This may suggest that fin-swimming like scuba diving could give a diver some degree of physical load without on increased heart rate.