Résumé
Background: As the medicine advanced, drug therapy became one of the most important and effective therapies in health care system. Which also raises the possibility of its mortality and morbidity. Drug-drug interaction [DDI] is defined as the occurrence of a harmful combination of prescribed drugs in a given patient. DDIs is a known cause of hospital visits, admissions and increases in health care use that could be prevented. In this study, we aimed to detect the DDIs prevalence in pediatric patients in King Abdulaziz university hospital[KAUH], Saudi Arabia
Methodology: Retrospective cross-sectional study on a sample taken from all pediatric patients at KAUH in Jeddah, Saudi Arabia between January - December 2106, with no exclusion criteria. We extracted the data from KAUH medical files. DDIs, severity and documentation of the DDIs were identified using micromedex. Data entry using microsoft office 2016. Data analysis using SPSS 21 and multivariate regression was done to assess the association of DDI with other factors
Results: Three hundred and fifty-nine patients were selected with the mean age [SD] 7.06 [5.9], 202 [56.2%] were male. A total of 233 DDIs were identified in 64 [17.8%] of the patients with the mean [SD] 3.64 [3.52]. Of all identified DDIs, the severity classification was: major [123 [52.79%]], moderate [67 [28.76%]], minor [37 [15.88%]] and contraindicated [6 [2.58%]]. The documentation of DDIs was excellent [9 [3.8%]], good [89 [38.2%]] and fair [135 [58%]]. Significant association with medications number 5 or more had been suggested
Conclusion: The prevalence of DDIs although much less than other studies but the higher proportion of major severity. Patients 1-3 years of age and those on 5 or more medications need more strict monitoring as they have more risk to have DDIs
Résumé
Background: most of articles addressed the underlying causes and management of Neonatal Nonhemolytic Jaundice, however only a few have investigated nonhemolytic jaundice among infancy which can turn fatal in severe case, however can be prevented by early diagnosis
Aim of the Work: was to investigate the most common etiologies of nonhemolytic jaundice among infants presented to at King Abdulaziz University Hospital [KAUH] which may help pediatricians to rearrange their differential diagnosis about nonhemolytic jaundice in infants
Material and Methods: this is a retrospective observational study of all infants aged between 1-12 months, conducted at King Abdulaziz University Hospital [KAUH] in Jeddah, Saudi Arabia from January 2016 to November 2017. Data collection was done using Microsoft Excel while data analysis was done using SPSS version 21. Chi -square test was used to test if associations would be appropriate
Results: out of total 105 patients enrolled in this study, complete data set was available for 88 only patients during 2012. The mean age at presentation in months was 2.73 [+/- SD 2.21] range from 1 to 12 months. Among the sample, the final outcome was as follows ; 59 [67%] jaundice-free, 14 [15.9%] still diseased and 15 [17%] dead. Sepsis was the most common cause of jaundice with 33 cases [37.5%], followed by biliary atresia 10 cases [11.4%] and congenital hypertrophic pyloric stenosis 7 cases [8%]. On the other hand, the least common causes were rare diseases like wolman syndrome, crigler-najjar syndrome and autoimmune hepatitis and each of them represents 1 case. The overall number of deaths in our study was 15 [17%]. Seven of them were due to sepsis and 2 were due to biliary atresia
Conclusion: we hope to help the local physicians in Jeddah to arrange their differential diagnosis of nonhemolytic jaundice among infants and deal with it seriously, due to the high incidence of critical illness and death