Résumé
In this study, four formulae of effervescent powder, suggested to contain 100 mg CBZ, were evaluated for their effervescence tests, humidity content as well as content uniformity. Three formulae of tablets were suggested and contained 100 mg CBZ. They were examined by weight variation test, disintegration and dissolution rate tests. Also, three formulae of capsules, containing 100 mg CBZ, were prepared and evaluated by weight variation, content uniformity and dissolution rate tests. It was evident that CBZ crystal 1 effervescent powder formula 4 and its capsule formula 3 were the best and they were subjected for a stability study at room temperature for one year. In addition, the anticonvulsant activity of the CBZ prepared formulations in mice was performed using the maximal electroshock method. For comparison, commercially available formulations; namely, Tegretol 200 tables and Tegretol suspension [100 mg/5 ml], were also evaluated