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1.
Annals of the Academy of Medicine, Singapore ; : 371-377, 2014.
Article Dans Anglais | WPRIM | ID: wpr-312264

Résumé

<p><b>INTRODUCTION</b>This study aims to review the results of hearing screens in newborns with cleft deformities.</p><p><b>MATERIALS AND METHODS</b>A retrospective audit of 123 newborns with cleft deformities, born between 1 April 2002 and 1 December 2008, was conducted. Data on the results of universal newborn hearing screens (UNHS) and high-risk hearing screens, age at diagnosis, severity/type of hearing loss and mode of intervention were obtained from a prospectively maintained hearing database.</p><p><b>RESULTS</b>Thirty-one of 123 newborns (25.2%) failed the first automated auditory brainstem response (AABR). Seventy percent of infants (56 out of 80) who passed the UNHS failed the high-risk hearing screens which was conducted at 3 to 6 months of age. Otolaryngology referral rate was 67.5% (83/123); 90.3% of 31 newborns who failed the first AABR eventually required otolaryngology referrals. Incidence of hearing loss was 24.4% (30/123; 25 conductive, 2 mixed and 3 sensorineural), significantly higher than the hospital incidence of 0.3% (OR: 124.9, 95% CI, 81.1 to 192.4, P <0.01). In terms of severity, 8 were mild, 15 moderate, 5 severe, 2 profound. Eighteen out of 30 infants (60%) were detected from the high-risk hearing screens after passing the first AABR.</p><p><b>CONCLUSION</b>These newborns had a higher risk of failing the UNHS and high-risk hearing screen. There was a higher incidence of hearing loss which was mainly conductive. Failure of the first AABR was an accurate predictor of an eventual otolaryngology referral, suggesting that a second AABR may be unnecessary. High-risk hearing screens helped to identify hearing loss which might have been missed out early on in life or which might have evolved later in infancy.</p>


Sujets)
Humains , Nouveau-né , Bec-de-lièvre , Fente palatine , Perte d'audition , Dépistage néonatal , Études rétrospectives
2.
Annals of the Academy of Medicine, Singapore ; : 74-77, 2007.
Article Dans Anglais | WPRIM | ID: wpr-275229

Résumé

<p><b>INTRODUCTION</b>We report a case of successful rehabilitation of hearing with a cochlear implant in a patient with nasopharyngeal carcinoma who developed post-irradiation hearing loss following treatment.</p><p><b>CLINICAL PICTURE</b>A 55-year-old Chinese lady suffered from radiation-induced sensorineural hearing loss due to treatment for nasopharyngeal carcinoma. Audiological tests and imaging studies showed an intact retrocochlear pathway.</p><p><b>TREATMENT</b>Cochlear implantation.</p><p><b>OUTCOME</b>Cochlear implant was done with successful rehabilitation of hearing until the time of this report.</p><p><b>CONCLUSIONS</b>If functionally active auditory fibres survive with no recurrent tumour, successful rehabilitation of post-irradiation induced sensorineural hearing loss is possible with a cochlear implant in a patient with nasopharyngeal carcinoma.</p>


Sujets)
Femelle , Humains , Adulte d'âge moyen , Audiométrie électroencéphalographique , Implants cochléaires , Perte d'audition , Réadaptation , Surdité neurosensorielle , Réadaptation , Tumeurs du rhinopharynx , Radiothérapie
3.
Annals of the Academy of Medicine, Singapore ; : 104-107, 2006.
Article Dans Anglais | WPRIM | ID: wpr-300143

Résumé

<p><b>INTRODUCTION</b>The development of secondary tumours as a result of radiation therapy is a rare but serious complication.</p><p><b>CLINICAL PICTURE</b>This is a case report of a 45-year-old Chinese male who developed postirradiation sarcoma of the sphenoid bone in less than 5 years after radiation therapy for Stage T3N1M0 nasopharyngeal carcinoma.</p><p><b>DISCUSSION</b>In the literature, the only case of postirradiation osteosarcoma of the sphenoid bone was after radiation therapy for craniopharyngioma. There was no previously reported case of postirradiation sarcoma of the sphenoid bone after radiation therapy for nasopharyngeal carcinoma.</p><p><b>CONCLUSION</b>This is the first case of postirradiation malignant fibrous histiocytoma of the sphenoid to be reported. Of about 3000 patients treated with radiotherapy for nasopharyngeal carcinoma over a 10-year period in Singapore, only 1 patient developed postirradiation tumour of the sphenoid bone.</p>


Sujets)
Humains , Mâle , Adulte d'âge moyen , Tumeurs osseuses , Issue fatale , Histiocytome fibreux malin , Imagerie par résonance magnétique , Tumeurs du rhinopharynx , Anatomopathologie , Radiothérapie , Tumeurs radio-induites , Os sphénoïde , Anatomopathologie , Tumeurs du rachis , Radiothérapie
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