A Case of Ganglioneuroma in Retroperitoneum / 대한비뇨기과학회지

Ganglioneuromas have their origin in neural crest and are found along the path of the sympathetic chain from the base of the skull to the pelvis, including the adrenal medulla. Clinically, ganglioneuromas may be incidentally found or detected secondarily by pressure effects on adjacent structures. Endocrine activity is rare among ganglioneuromas. Symptoms and signs such as hypertension, profuse perspiration, cutaneous flushing, rash, pallor, polyuria, and diarrhea are well documented. Recently we experienced a case of ganglioneuroma arising from the retroperitoneal sympathetic chains in a 46 year-old-female and, herein, report with review of the literatures.

Multiple Primary Malignant Neoplasms in Genitourinary Tract / 대한비뇨기과학회지

The phenomenon of multiple primary malignant tumors in one patient synchronously or metachronously is no more curiosity. So, careful follow up study and early diagnosis of those lesions, based on an awareness of the possibility of the second cancer, will substantially increase the survival of these patients. We collected nine cases of multiple primary cancers according to Moertel's classification histologically proved and treated from 1985 to l992 at Kosin Medical Center. The results were as follows; 1. The average age of the patients was 60.9 years with dominance in seventh decade 2. The male to female ratio was 7: 2 with significant dominance in male. 3. The synchronous to metachronous ratio was 6: 3, in metachronous cases the average time interval between 1st and 2nd cancers was 122 months. 4. In 6 cases of synchronous cancers, there were penile cancer and hepatoma, renal cell carcinoma and bladder cancer, prostatic cancer and bladder cancer, bladder cancer and colon cancer, and prostatic cancer and lung cancer. In 3 cases of metachronous cancers, there were bladder cancer and uterine cervical cancer, bladder cancer and stomach cancer, and renal cell carcinoma and synovial sarcoma. 5. In 3 cases of metachronous cancers, adjuvant therapy was performed in 2 cases after operation including one case of chemotherapy and another case of radiotherapy.

Surgical Treatment of 20 Cases of Adrenal Tumors / 대한비뇨기과학회지

Our experience of surgical management of 20 adrenal tumors was present during the period from June, 1988 to May, 1993. The results of clinical study were as follows ; 1. Average age of patients was 40.9 years with the highest incidence in sixth decade occupying 40% and male to female ratio was 1:1 and right to left ratio was equal also. 2. The adrenal tumors consist of 8 adrenocortical adenoma( including 3 primary aldosteronisms and 1 Cushing syndrome), 4 adrenocortical carcinoma(including 1 Cushing syndrome), 7 pheochromocytomas and l neuroblastoma. 3. The 11 functioning adrenal tumors( including 4 adrenocortical adenomas, 1 adrenocortica1 carcinoma and 6 pheochromocytomas) showed specific symptoms and signs and the majority symptom and sign of the 9 non-functioning adrenal tumors( including 4 adrenocortical adenomas, 3 adrenocortical carcinomas, 1 neuroblastoma and 1 pheochromocytoma) showed abdominal discomfort and pain. 4. For initial diagnosis of the adrenal tumors, USG, CT, MRI and angiography are reliable but IVP was reliable in large adrenal tumor 5. The surgical approaches were transperitoneal in 18 patients and retroperitoneal in 2 patients and postoperative surgical complication occurred in 3 patients of transperitoneal approaches that were prolonged ileus, spleen injury and pancreatic injury with pleural effusion.6. The tumor masses were 12gm to 4,000gm in weight (mean: 616gm). The adrenal benign and malignant tumor were significantly different in weight ( 120gm : 1817gm).

A Case of Brain Metastasis from Prostatic Adenocarcinoma Which Showed Remarkable Effect in Combined Chemotherapy / 대한비뇨기과학회지

The brain metastasis of prostatic carcinoma is rare and is distinguished by its poor prognosis in cases which are not surgically resectable. Herein we described a 72 year old male with brain metastasis from prostatic carcinoma, which regressed with chemotherapy. Pathological examination of a transrectal needle biopsy disclosed moderatedly differentiated adenocarcinoma of the prostate. Magnetic resonance imaging of brain demonstrated a brain tumor at the occipital lobe suspected to be a metastasis of prostatic carcinoma. The tumor could not be detected on the brain MRI after 3 months of chemotherapy.

Clinical significance of measurements of serum CA19-9 in genitourinary cancer / 대한비뇨기과학회지

We measured serum CA19-9 from March 1990 to June 1992 in 63 cases of normal controls, 56 cases or bladder cancer, 32 cases of renal cell carcinoma, 8 cases of prostatic carcinoma, 4 cases of penile cancer. 2 cases of testicular cancer and 3 cases of carcinoma of gastrointestinal tract with metastasis to the retroperitoneum. The results of this study were that serum levels of CA19-9 in urinary bladder cancer, renal cell carcinoma and prostatic carcinoma were statistically significant. However, sensitivity was low, 14. 29% for urinary bladder cancer, 18.75% for renal cell carcinoma. 12.5 % for prostatic carcinoma and specificity was 95.2%. In renal cell carcinoma, there was no change in serum level between stages. However there was a statistically significant difference (p<0.05) between low stage(A, B) and high stage(C, D) urinary cancers. We suggest that serum CA19-9 levels cannot be used as a screening test or prognosis indicator in tumors of the genitourinary tract ; however it can be helpful in differentiating between low and high stage urinary bladder cancers.

Two cases of small cell carcinoma of the prostate with fulminant progression / 대한비뇨기과학회지

We managed the two cases of small cell carcinoma of prostate, which has been reported only 20 cases in the world literature. It has not been reported in our country. It`s prognosis is very poor and it may have neurosecretory manifestation. Small cell carcinoma of the prostate combined with adenocarcinoma or previous history of adenocarcinoma is found in 50% cases. The diagnosis was established by pathologic findings with special stain (neuron specific enolase) and electromicroscopic examination.

Therapeutic effect of PVB chomotherapy after cytoreductive surgery on a case of seminoma developed in abdominal cryptorchid testes / 대한비뇨기과학회지

Testicular tumors were reported sporadically in Korea. Seminomatous germ cell tumor is the most frequent tumor in the testis and it is treated highly effectively with irradiation and/or chemotherapy according to stage. Herein we report a relatively rare case of seminoma developed in abdominal cryptorchid testis of 28 years old male. which was treated with PVB chemotherapy after cytoreductive surgery. Histopathological examination revealed seminoma of stage II B(T3N2MO) by M.D. Anderson hospital classification Postoperative PVB chemotherapy was performed and the tumor was completely remitted at follow up study for 4 years.

Two cases of squamous cell carcinoma with staghorn calculi which were progressed fulminantly / 대한비뇨기과학회지

We report two cases or squamous cell carcinoma with transitional cell carcinoma synchronouely developed in renal pelvis at a 51 years old male and a 69 years old female who had large renal calculi. Excretory urograms showed non-visualization of diseased kidneys with staghorn calculi and these patients were underwent nephrectomy. On operation, in both cases, each kidney severely adhered to adjacent fat tissue. Postoperative pathologic result was shown to squamous cell carcinoma with high grade transitional cell carcinoma in each cases. These patients were expired within 6 months.