Serum levels of a filaricide, diethylcarbamazine citrate, in cats following different routes of administration.

We have reported the blood levels of diethycarbamazine (DEC) and the persistence of the drug in the circulation for several routes and protocols of DEC administration in cats. This information will be helpful in studies using the Brugia-cat model for studies of experimental chemotherapy.

Efficacy of oral and transepidermal application of diethylcarbamazine citrate in Brugia malayi infected cats.

This experimental study showed that daily oral administration of DEC at levels of 5 to 15 mg/kg/day with food for 3 weeks decreased the level of both developing and adult B. malayi in infected cats. There were no adverse reactions due to the medication. Topical application of 5% DEC in skin cream or in mineral oil appears to be effective in killing developing B. malayi in cats.