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1.
Indian J Physiol Pharmacol ; 2006 Apr-Jun; 50(2): 143-51
Article Dans Anglais | IMSEAR | ID: sea-106542

Résumé

The research work deals with the screening of ethanol and chloroform extracts of Pachyrrhizus erosus seeds for central nervous system (CNS) depressant activity. The Pachyrrhizus erosus seed is known to contain rotinoids, flavonoids and phenylfuranocoumarin derivatives as chemical components and is reported to have antifungal, antisecretory, insecticides, antibacterial and spasmolytic activity. Since seeds of Pachyrrhizus erosus is used as folk medicine in treatment of insomnia, we made an attempt to study its CNS depressant effect. The different activities studied were potentiation of pentobarbitone-induced sleep, test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiety activities. The result of the study reflected that ethanol extract of the seeds (150 mg/kg, p.o) decreased locomotor activity, produced muscle relaxation and showed antianxiety and antiaggressive activity.


Sujets)
Agressivité/effets des médicaments et des substances chimiques , Animaux , Anxiolytiques/pharmacologie , Dépresseurs du système nerveux central/pharmacologie , Femelle , Hypnotiques et sédatifs/pharmacologie , Mâle , Apprentissage du labyrinthe/effets des médicaments et des substances chimiques , Souris , Activité motrice/effets des médicaments et des substances chimiques , Myorelaxants à action centrale/pharmacologie , Pachyrhizus/composition chimique , Extraits de plantes/pharmacologie , Graines/composition chimique
2.
Indian J Exp Biol ; 1990 Mar; 28(3): 237-40
Article Dans Anglais | IMSEAR | ID: sea-56922

Résumé

Urolithiasis, following implantation of Zn discs in urinary bladder (foreign body insertion technique), was examined in albino rats of either sex. Marked variation was observed between sex, regarding the formation of bladder stones. Ethylene glycol (1%) mixed in drinking water for 4 weeks, was unable to augment Zn disc-induced stone deposition. Chemical nature of stones was identified as of magnesium ammonium phosphate type. Neither urinary pH nor infection in the urinary bladder/tract affected chemical nature and quantity of stone formed. There was no significant influence of electrolytes or metabolic products on the uroliths. No correlation could be drawn between the quality and quantity of uroliths formed and the urinary electrolytes concentration. M. Pudica was not effective in either preventing stone deposition or dissolving preformed stones.


Sujets)
Animaux , Calcium/urine , Électrolytes/urine , Femelle , Concentration en ions d'hydrogène , Mâle , Extraits de plantes/pharmacologie , Plantes médicinales , Rats , Lignées consanguines de rats , Calculs urinaires/urine , Zinc
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