Résumé
Standards for Prescription Review in Medical Institutions puts forward higher requirements for the pharmacists' ability to review prescriptions, and the dispensing pharmacist should review the legality, standardization, and suitability of the prescription. Centralized training helps to improve the pharmaceutical care capacity and promote the rational use of drugs in hospitals. The centralized training course system designed by our hospital includes four modules: laws and regulations, prescription suitability review for drugs commonly used in each department, prescription suitability review for drugs used in the special population, and prescription suitability review for specialty drugs. The training system has the characteristics of homogeneity and standardization. A combination of theoretical courses and practical exercises, as well as the introduction of problem-based learning and case-based learning, holds promise for application in the training of dispensing pharmacists.
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Objective To standardize the method of microbiological examination on Shegan Mixture in Chinese Pharmacopoeia 2015. Methods Chinese Pharmacopoeia 2015 was used. Microbial enumeration test and specified microorganisms test were used to verify Shegan Mixture. The samples were treated by membrane filtration. Six kinds of strains for microbiological counting and limiting bacteria were used to study applicability. Results Microbial counts of the five strains of the recovery ratio were between 0.5 to 2, and Escherichia coli tested by control bacteria was qualified. Conclusion The microbiological examination methods for Shegan Mixture can meet the requirements of Chinese Pharmacopoeia 2015.
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Objective To assess the efficacy and safety of lamotrigine for absence seizures in children and adolescents . Methods Databases of PubMed ,the Cochrane Library ,EMbase ,CENTRAL ,VIP ,WanFang ,CBM and CNKI were electron-ically searched till August ,2014 for clinical trials on lamotrigine for absence seizures in children and adolescents .All literature were screened by two reviewers independently according to the inclusion and exclusion criteria .The data was extracted ,and the methodological quality was assessed .Then ,meta-analysis was performed using RevMan 5 .2 .Results Seven trials were in-cluded involving a total of 721 patients .The results of methodological qualities were two studies rated as A-class ,three studies rated as B-class and two studies rated as C-class .Meta-analysis results showed that the efficacy of lamotrigine monotherapy for absence seizure in children and adolescents was better than placebo ,but efficacy of lamotrigine was lower than valproic acid and ethosuximide .The adverse reaction rates of lamotrigine were with no significant difference compared with valproic acid and et-hosuximide .Conclusion Lamotrigine monotherapy was effective for absence seizures in children and adolescents and was well tolerated .Lamotrigine was a good choice for patients that are intolerable to valproic acid or ethosuximide .
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Objective:To establish a simple HPLC method for the determination of warfarin in human plasma and analyze the re-sults of 100 monitoring reports. Methods:Warfarin was extracted from the plasma samples by acetonitrile. The extract was separated on a ZORBAX Eclipse XDB-C8 column (150 mm × 4. 6 mm, 5 μm)with a mobile phase consisting of methanol and 0. 1% acetic acid (65∶35) at flow rate of 1. 0 ml·min-1 and detected by a diode array detector. The detection wavelength was at 308nm and the sample size was 20 μl. Results:The calibration curve was linear within the range of 0. 1-5. 12μg·ml-1 . The average recovery and RSD was ranged from 85. 0% to 102. 3% and 1. 2% to 3. 9%(n=6), respectively. Inter-and intra-day RSD were 1. 1%-1. 8% and 1. 6%-2. 9%, respectively. Conclusion:The proposed method is rapid, convenient and accurate in the detection of warfarinin concentration in plasma.
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OBJECTIVE:To investigate the application of vancomycin in pediatric patients.METHODS:By reviewing medical histories of 368 pediatric patients who had been treated with vancomycin from 2005 to 2006,the use of vancomycin was investigated in respect of children' general condition,microbiological examination,dosage regimen,adverse drug reactions to evaluate the rationality of drug use.RESULTS:ADR occurred in 17 cases(4.6%).The use of vancomycin was rational or basically rational in 240 cases(65.2%).CONCLUSION:It is necessary to tighten more strict control on the use of vancomycin in pediatric patients.