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Traditional treatments for malignant tumor are far from meeting the clinical demands.Recently,research on anti-tumor targeted drugs has made a significant breakthrough,which brings new hope for the treatment of malignant tumor.Anti-tumor targe-ted drugs can specifically target malignant tumor and directly in-hibit the growth of tumor cells,showing no toxicity to the normal tissues and organs.Herein we reviewed the research progress of small molecular targeted drugs and antibody targeting new drugs.
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OBJECTIVE: To observe the effects of astragalus polysaccharides(APS) combining with total ginsenoside (TG) on the proliferation of T cells in peripheral blood of healthy adults and on the immune function of mice after treatment with cyclophosphamide (CY) . METHODS: The proliferation rate of T cells in peripheral blood was detected by methyl thia-zolyl tetrazolium(MTT) colorimetric analysis; the weight of immune organs such as spleen and thymus etc. in mice were detected. RESULTS: The proliferation of T cells in human peripheral blood could be enhanced if the concentration of APS remained within 25-100?g/ml and that of TG remained within 5-20?g/ml; the proliferation rates were 102.3%-141.1% and 113.9%-163.1% , respectively; the figure stood at 262.3%-383.0% when APS and TG used in combination. The spleen indexes of APS group and the APS plus TG group increased significantly vs. the CY group(P
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OBJECTIVE: To establish an HPLC method for the determination of fumaric acid in Pleurotm citrinopileatus. METHODS: HPLC was performed on Yilite C18 column(250 mm?4.6 mm,5 ?m) with methanol-0.01 mol?L-1 potassium dihydrogen phosphate solution(5 ∶ 95,pH adjusted to 2.5 using phosphoric acid) as mobile phase and detection wavelength of 216 nm. RESULTS: The linear range of fumaric acid was 0.16～1.6 ?g (r=0.999 9). The average recovery was 101.59% (RSD=1.28%,n=6). CONCLUSION: This method is accurate, simple and reproducible for the content determination of fumaric acid in P. citrinopileatus.
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Ethyl acetate extract of Tripterygium wilfordii (20mg/kg, 40mg/kg ), given to adjuvantarthritis rats (ig ) for 7 consecutive days, markedly decreased both high and low shear whole blood viscosity, plasma viscosity, whole blood reduction viscosity, hematocrit and fibrinogen content, but without effect on blood sedimentation and K value in blood sedime ntation equation. These resuits indicated that the decreasing effect of T. wilfordii on bloodviscosity ma y be related to ius influenee on red blood cells and plasma composition.