Research progress on topoisomerase Ⅰ inhibitors / 中国药理学通报

Following the realization that involved in all of the key process within the cell nucleus such as DNA replication,transcription,reorganization,repair,human DNA topoisomerase Ⅰ(Topo Ⅰ) is a useful therapeutic target against tumor growth.Topo Ⅰ inhibitors represent a class of effective agents that have been extensively exploited and used for carcinomachemotherapy.Current Topo Ⅰ inhibitors being clinically used or developed are classified as campotothecins and non-camptothecins.This presentation introduces current status and trends of Topo Ⅰ inhibitors as anti-tumor agents with an emphasis on bioactive and pharmacological properties of these agents.