RÉSUMÉ
Objective To investigate the association between ?_(2)-bradykinin receptor(?_(2)-BKR) gene and angiotensinogen gene polymorphism and essential hypertension.Methods The casecontrol study was conducted using MS-PCR and PCR-SSCP techniques to explore the ?_(2)-BKR gene-58T/C polymorphism and the AGT gene M235T polymorphism in 97 essential hypertensives and 87 normotensives of Shenzhen.Results The genotypes distribution of CC and the alletic frequency of C in EH cases were significantly higher than in controls(0.36 vs 0.14,P=0.000;0.60 vs 0.43,P=0.001).The genotype distributions of CC+MT and TC+MM in EH cases were significantly higher than controls(0.19 vs 0.06,P=0.009;0.18 vs 0.05,P=0.006).The odds ratio for those exposed to CC genotype was 1.913,95% confidence interval was 1.913 to 3.049,P=0.006.No significant difference was seen in the genotype distribution of angiotensinogen gene between EH cases and controls(P=0.091),but the alletic frequency of M in EH cases was significantly higher than controls(0.55 vs 0.44,P=0.037).Conclusion The ?_(2)-BKR gene-58T/C polymorphism might be associated with essential hypertension in Shenzhen population.CC genotype might be associated with the increased risk of EH and C allele might have a gene-gene synergetic effect with M235T polymorphism.