Résumé
In addition to the central and the peripheral nervous system, calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) has been identified throughout the enteric nervous system. Several functions of the CGRP in gastrointestinal (G-I) tract has been identified, but the effect of CGRP on G-I motility is unclear. The distribution of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) in the murine small bowel were studied by using immunohistochemistry, also analyzed functionally by using electrophysiological method. Immunohistochemical studies demonstrated that CGRP-LI is localized in both nerve fibers and myenteric ganglion cells in the whole-mount preparation of murine small intestine. Double labelling with CGRP and c-kit investigated by confocal microscope was shown that CGRP-LI enteric nerve fiber surrounded the c-kit positive interstitial cells of Cajal (ICC). Electrophysiological finding revealed that treatment of CGRP inhibited electrical activity on culture ICC. Our results suggest a CGRP innervation of murine small bowel ICC. The released CGRP from enteric nerve terminals may induce relaxation of small bowel through the inhibition of ICC.
Sujets)
Animaux , Souris , Peptide relié au gène de la calcitonine , Calcitonine , Système nerveux entérique , Pseudokystes mucoïdes juxta-articulaires , Immunohistochimie , Cellules interstitielles de Cajal , Intestin grêle , Neurofibres , Système nerveux périphérique , RelaxationRésumé
Bronchial mucoepidermoid carcinoma is very rarely encountered in children. We report a case of bronchial mucoepidermoid carcinoma in a 10-year-old boy who presented with persistent cough and atelectasis. Bronchoscopic examination showed a tumor mass occluding the right bronchus intermedius, and the mass was removed by bronchoscopy. The results of the pathological examination revealed low-grade mucoepidermoid carcinoma. He underwent right middle and lower lobectomy with bronchoplasty, and there was no metastasis. He remains symptom-free without recurrence of bronchial tumor during the follow-up period of 12 months.
Sujets)
Enfant , Humains , Mâle , Bronches , Bronchoscopie , Carcinome mucoépidermoïde , Toux , Études de suivi , Métastase tumorale , Atélectasie pulmonaire , RécidiveRésumé
Idiopathic long QT syndrome(LQTS) is an important cause of syncope, seizures, serious ventricular arrhythmias and sudden death in children. The abnormalities of AV conduction such as 2:1 AV block in children with LQTS is rarely reported. We reported two cases of 2:1 atrioventricualr block in infants with LQTS. Patient 1, a female newborn, revealed bradycardia(60 beats/min) and QTc of 0.65sec with 2:1 AV block at birth. She died of polymorphic ventricular tachycardia at 26days of age. Patient 2, a 2-month-old female, exhibited prolonged QT interval (QTc=0.54sec), 2:1 AV block, and intermittent Wenckebach conduction. After she received propranolol, sinus rhythm with 1:1 AV conduction and QTc of 0.5sec was seen. After a follow-up of 6 months, the infant is still doing well.
Sujets)
Enfant , Femelle , Humains , Nourrisson , Nouveau-né , Troubles du rythme cardiaque , Bloc atrioventriculaire , Mort subite , Études de suivi , Syndrome du QT long , Parturition , Propranolol , Crises épileptiques , Syncope , Tachycardie ventriculaireRésumé
Fetal hydrops describes the infant who has generalized edema due to accumulation of exess fluid, in serious case, ascites and pleural and pericardial effusions are commonly combined. The chorioangioma is considered the most common primary tumor of the placenta, which is about 1% of all pregnancy. However, the majority of the cases are asymptomatic but larger ones, usually more than 5cm in diameter, are commonly associated with maternal and fetal complications. We report a case of nonimmune hydrops fetalis due to large chorioangioma with associated polyhydramnios. The newborn infant was managed conservatively and had excellent outcome.
Sujets)
Humains , Nourrisson , Nouveau-né , Grossesse , Ascites , Oedème , Hémangiome , Anasarque foetoplacentaire , Épanchement péricardique , Placenta , PolyhydramniosRésumé
Fetal hydrops describes the infant who has generalized edema due to accumulation of exess fluid, in serious case, ascites and pleural and pericardial effusions are commonly combined. The chorioangioma is considered the most common primary tumor of the placenta, which is about 1% of all pregnancy. However, the majority of the cases are asymptomatic but larger ones, usually more than 5cm in diameter, are commonly associated with maternal and fetal complications. We report a case of nonimmune hydrops fetalis due to large chorioangioma with associated polyhydramnios. The newborn infant was managed conservatively and had excellent outcome.
Sujets)
Humains , Nourrisson , Nouveau-né , Grossesse , Ascites , Oedème , Hémangiome , Anasarque foetoplacentaire , Épanchement péricardique , Placenta , PolyhydramniosRésumé
In two female siblings, growth and developmental retardation, poor sucking, anorexia, floppiness and respiratory difficulty developed around 2 and 4 monthes of age in each, and the respiratory symptoms rapidly aggravated to comatose states and finally into death one month later. On admission at emergency room, severe acidosis and high lactate and pyruvate levels in serum and cerebrospinal fluid were revealed in one. Brain computed tomography and magnetic resonance imaging revealed identical bilateral involvement of putamen in both of the sibs, which made the diagnosis of Leigh disease(subacute necrotizing encephalomyelopathy) possible. There is also a family history of early death in infancy period; an elder sister and a brother of mother died with unknown cause at their 5 and 10 months of age. Mitochondrial enzyme functions could not be assayed.